Syme was born in
Pico Rivera, California, and was raised in
Laguna Beach. Her parents were Maria St. John and Charles Syme, a retired California highway patrol officer; She introduced Lynch to many of the musicians he used in his projects, and according to Coffey, she had a huge influence on the music in the film
Lost Highway (1997). Syme also did some acting, and Scott Coffey directed her in five independent short films. The last one,
Ellie Parker, was shown at the
Sundance Film Festival in January 2001. In 1997, Syme made her film debut in a small role credited as "junkie girl" in David Lynch's
Lost Highway. Syme had a small role credited as "casting chick" in
Scott Coffey's film
Ellie Parker, released in 2005, reprising the role she played in the 2001 short film of the same title. At the time of her death in 2001, Syme had enrolled in a film-supervision course at
UCLA, ==Personal life==