Immediately after ordination Fr Vaughan was appointed to the staff of the recently opened
St. Bede's College as Professor of Mathematics, however he resigned in November of that same year following a breakdown in health and was invited by his brother Bishop
Roger Vaughan to come and undertake Missionary work in
Australia. He returned to England in July 1879 and rejoined the staff of St Bede's in his former role as Professor of Mathematics, where he remained until July 1886. In 1886, Fr Vaughan was invited by his brother Fr Kenelm Vaughan to join him at his new venture 'The House of Expiation' in
Chelsea, London. In 1896, he was appointed domestic
prelate to the
Papal Court with the title
Monsignor and in 1898 became
Canon of
Westminster. Between 1890 and 1903, he organized free
Catholic lectures in various public halls in London. He resided in Rome from 1904 to 1907, and then undertook a preaching tour in the United States and Canada. In 1909, Monsignor Vaughan returned to England and was sent back to the
Diocese of Salford to assist Bishop
Louis Charles Casartelli as his auxiliary bishop, he was assigned the title of Titular Bishop of Sebastopolis and was consecrated in
Westminster Cathedral on the 5 August 1909. Coming to Manchester he initially resided at
Xaverian College until 1912 when he returned to
St. Bede's College as
Rector. In 1915 he took up residence at
St Joseph's College, Upholland near Wigan. In 1920 became Parish Priest at St Hubert's Church in
Great Harwood where he died five years later on 4 December 1925 at the age of seventy-two. ==Published works==