After finishing his college basketball career at South Carolina, Jefferson was not drafted by any
NBA team. He signed for the 2011–12 season with the
Iskra Svit in Slovakia. On August 29, 2013, he signed a one-year deal with Italian club
Pallacanestro Mantovana of the
Serie A2 Basket. On July 23, 2014, he re-signed with Mantovana for one more season. On February 4, 2015, he was suspended by Mantovana. Six days later, he left the club and signed with
Pallacanestro Varese for the rest of the
2014–15 Serie A season. On July 11, 2015, he signed with Turkish club
Torku Konyaspor for the
2015–16 season. On July 21, 2016, Jefferson signed with Italian club
Aquila Basket Trento. On January 6, 2017, he parted ways with Trento after averaging 10.5 points and 7.2 rebounds in eleven games. On February 25, 2017, he signed with Turkish club
Afyonkarahisar Belediyespor for the rest of the season. On July 30, 2017, Jefferson signed with
Champville of the
Lebanese Basketball League. On October 1, 2018, Jefferson signed a one-year deal with
Cibona of the
ABA League and the
Croatian League. Cibona parted ways with him on December 24, 2018. Jefferson spent the rest of the 2018–2019 season with
PAOK Thessaloniki in Greece. On August 16, 2019, he has signed with
Chorale Roanne Basket of the
LNB Pro A. In May 2021, Jefferson was on the roster of Moroccan club
AS Salé for the
2021 BAL season. ==The Basketball Tournament==