While an engineering student in the Philippines, Briones became involved with the original 1989 London production of
Miss Saigon. Briones had a friend who was a producer in the Philippines, who asked Briones to help "facilitate an audition" for the Cameron Mackintosh team who were holding auditions in the Philippines for
Miss Saigon. In addition to helping with the organization of the auditions, Briones himself auditioned for and then became a member of the ensemble. He has been involved with various touring productions of
Miss Saigon, as a swing and covering other roles, finally playing the Engineer. In 2014 he joined the original cast of the
Miss Saigon West End revival, playing the Engineer. He was nominated for the
Laurence Olivier Award for Best Actor in a Musical for playing this role and won the
Whatsonstage.com Award for Best Actor in a Musical. He remained in the role until the production closed on February 27, 2016. In 2017, Briones transferred with the production to
Broadway at the
Broadway Theatre. Previews started on March 1, 2017, with an official opening on March 23. On April 30, 2019, Briones received the Visionary Award from
East West Players during their annual awards dinner and silent auction. The award is given to celebrate individuals that are able to raise the visibility of
Asian Pacific Americans through their work. During his acceptance speech, Briones said that his "vision is that we change hearts and minds in Hollywood and in the theatre community so they see that we have a voice and a story – beautiful stories – to tell, and
we are the ones who can and should tell it." In 2018, he appeared in
The Assassination of Gianni Versace: American Crime Story as Modesto Cunanan, father of
Gianni Versace's murderer,
Andrew Cunanan, and in
American Horror Story: Apocalypse as Ariel Augustus. In 2020, Briones appeared in the
Netflix drama series
Ratched, portraying Dr. Richard Hanover. In 2022, Briones appeared in the
second season of Star Trek: Picard. His daughter,
Isa Briones, is a main cast member on the series. In 2023, Jon Jon Briones played the role of Joseph in the movie 'The Last Voyage of the Demeter.' This drama/horror film tells the story of the crew of the merchant ship Demeter, who sail towards London to deliver a cargo of 50 unmarked wooden crates, only to discover that they are not alone. The presence of Dracula haunts them throughout the entire ship. In March 2024, Briones joined the cast of
Hadestown on Broadway, portraying
Hermes. He starred opposite his daughter, who made her Broadway debut as
Eurydice. ==Personal life==