SeniorWell, On Call San Francisco, MedicinePlanet, Private Medical Shlain made house calls to geriatric patients during his residency, and in 1996 founded a telemedicine service, SeniorWell, to help doctors communicate with older adults. In 1998, he learned that the
Mandarin Oriental in downtown San Francisco had no house doctor for guests needing medical attention. At the same time, he was the California medical director for Lufthansa and a member of the board of directors for the San Francisco Medical Society. Shlain co-founded MedicinePlanet, a website that provided global medical information for international travelers, in 2000. He served as MedicinePlanet's CEO until 2001,
HealthLoop, San Francisco Health Systems Board In 2008
Gavin Newsom, then the mayor of San Francisco, appointed Shlain to the Health Services Systems Board. As commissioner from 2010-2014, he developed policy and oversaw the allocation of healthcare funds for more than 45,000 city workers. It was his second governmental position: a 2004 appointee of
Willie Brown, he set entertainment and nightlife policy for the city and county of San Francisco as president of the San Francisco Entertainment Commission. In 2008, Shlain developed the prototype for HealthLoop, a
SaaS platform for doctors that used patient feedback and tracking data to monitor clinical areas of concern and facilitate follow-up. Shlain served as CEO of the company. An early application of AI, he was awarded a patent for pre-visit and follow-up systems and digital technology in 2013. A study in the
Journal of Arthroplasty found that the platform significantly improved patient outcomes and reduced healthcare costs. HealthLoop was acquired by GetWellNetwork in 2018.
Covid-19, public health, DOC, Eat Real Shlain treated
coronavirus patients as a frontline volunteer at clinics and facilities including
NewYork-Presbyterian Hospital at the height of the
COVID-19 pandemic in New York City. During the pandemic, he wrote about healthcare and health policy, served on expert panels, and sat for interviews with print and broadcast media outlets including
USA Today, The
Globe and Mail, and the
BBC. In addition, he co-wrote an April 2020
op-ed for
The New York Times that argued for smart quarantine, and published
Dispatches from the Front, a series of articles about staying healthy during the pandemic. In 2019, Shlain and
Robert Lustig founded Eat Real, a non-profit that partners with school districts to replace ultraprocessed school lunches for
K–12 students with nutrient rich and sustainably-sourced foods. In October 2025, with
John Battelle, he launched DOC, an invitation-only conference centered on health, longevity, and science. A "medicine-focused reincarnation of the early days of
TED", the inaugural two-day event took place in
the Napa Valley, == Personal life ==