Summary The first legs were played on 17 and 18 August, and the second legs were played on 23 and 25 August 2022. The winners of the ties advanced to the
group stage. The losers were eliminated from European competitions for the season.
Champions Path matches CFR Cluj won 1–0 on aggregate. ----
3–3 on aggregate; RFS won 4–2 on penalties. ----
Lech Poznań won 3–1 on aggregate. ----
Ballkani won 3–1 on aggregate. ----
2–2 on aggregate; Slovan Bratislava won 6–5 on penalties. Main Path matches Basel won 2–1 on aggregate. ----
Vaduz won 2–1 on aggregate. ----
Slavia Prague won 3–2 on aggregate. ----
Djurgårdens IF won 5–3 on aggregate. ----
Nice won 2–1 on aggregate. ---- ''2–2 on aggregate; Hapoel Be'er Sheva won 4–3 on penalties.'' ----
İstanbul Başakşehir won 4–2 on aggregate. ----
FCSB won 4–3 on aggregate. ----
Partizan won 7–4 on aggregate. ----
Fiorentina won 2–1 on aggregate. ----
Villarreal won 6–2 on aggregate. ----
1. FC Köln won 4–2 on aggregate. ----
West Ham United won 6–1 on aggregate. ----
1–1 on aggregate; Anderlecht won 3–1 on penalties. ----
Slovácko won 4–0 on aggregate. ----
Molde won 4–1 on aggregate. ----
AZ won 6–1 on aggregate. ==Notes==