After receiving his doctorate, Wu was a faculty member in the political science department at
Ohio State University and was deputy director of the Institute of
International Relations of
National Chengchi University in Taiwan. Formerly the Deputy Secretary General of the Presidential Office for President
Chen Shui-bian, Wu was appointed the minister of the
Mainland Affairs Council, the body charged with coordinating relations with
mainland China (
the People's Republic of China), by Chen in May 2004. His appointment as minister of the Mainland Affairs Council proved somewhat controversial due to his reputation as a supporter of
Taiwan independence, especially in light of the simultaneous appointment as
foreign minister of former independence activist
Mark Chen. His tenure as head of TECRO lasted one year and three months. In May 2016, Wu joined
Tsai Ing-wen's administration as Secretary-General of the
National Security Council. Following a brief tenure as
Secretary-General to the President from May 2017 to February 2018, he transitioned to the
Lai cabinet as
Minister of Foreign Affairs. He held this post for six years until the end of the
Presidency of Tsai Ing-wen in 2024. With the start of the
Presidency of Lai Ching-te in May 2024, he returned to his role as Secretary-General of the
National Security Council. ==Cross-strait relations==