Debono was a Professor of Medicine at the
University of Malta from 1946 to 1963. Professor Debono carried out original work on
vaccination of goats, together with Sir
Temistocles (Temi) Zammit, wrote many papers on
Undulant Fever (also known as the
Malta Fever) and introduced
Aureomycin, which was followed by other
antibiotics, in 1949. He was the first to popularize the concept of
dehydration in
Infantile Diarrhorea and introduced the simple but efficient treatment which greatly reduced mortality. Professor Debono was appointed consultant physician to the
Lazaretto Isolation Hospital in 1942 (during the worst part of the
Second World War), and was in charge of the
polio patients until the post war
epidemic was over. In 1963 he started an independent diabetic clinic and had continued for many years to serve as its director. ==Work in the diabetes field==