Joseph Johnson (1776–1862) was the twenty-seventh mayor of Charleston, South Carolina, serving two terms from 1825 to 1827. He was re-elected to his second term on September 4, 1826. He also was the president of the Branch Bank of the United States from 1818 until its close and authored a work titled "Traditions of South Carolina." Johnson died on October 6, 1862, in Pineville, South Carolina. In his youth he operated the leading drug store in Charleston.