Watkins passed through
Harrison, Ohio, on the way to Cadiz to retrieve his new bride. There he met one Dr. Richard Ward, the manufacturer of a popular vegetable anodyne
liniment for relieving muscle pain. This medicine was well known in Minnesota already through the sales franchise of J. H. Sands established in 1856. Watkins had an interest in the product and negotiated a franchise of his own from Dr. Ward. Watkins had a special buggy sales wagon made in
St Cloud, Minnesota. It was a large wooden-covered wagon with compartments and a high seat in front. It cost five hundred dollars with the horses. Watkins started to experiment with making the red liniment at his home in
Plainview, Minnesota in 1868. He personally bottled the home-made medicine of Asian
camphor and red pepper extract and sold it to the public. This became the founding of
J. R. Watkins Medical Company. Watkins sold his product directly to the local farmers and villagers, being credited as the founder of the direct sales industry. Watkins at first pushed a cart as a one-man operation. Later he peddled his business with a
horse and buggy sales wagon filled with products, developing a sales territory around his hometown. The direct door-to-door business was so successful that he brought in other wagon salesmen who sold throughout Minnesota and eventually to other states. Watkins built his business on customer satisfaction and extended the first
money back guarantee in the country for his product. He had a "trial mark" molded onto each bottle – positioned about one-third of the way down – and promised customers that if they hadn't used the product below that point, they would receive a full refund if they were unsatisfied. Watkins moved his business to
Winona, Minnesota in 1885. There it was easier to obtain the materials for his medical products. He rented a four-room house and used half for manufacture of his home remedy medical products – liniment, extracts, and salves. These products were purchased by lumbermen for relief of sore muscles from working all day in a sawmill. After establishing in Winona, Watkins expanded into publishing in 1898 with
The Morning Independent, a Democratic rival to the
Winona Daily Republican. Watkins sold the paper to Horace G. White and Frank J. Rucker in 1902, which was later sold to the Winona Republican-Herald in 1919. == Family ==