Spence was born on 28 April 1699, at
Kingsclere, Hampshire, the son of Joseph (Rector of Winnal in
Winchester and
Precentor of
Winchester Cathedral) and Mirabella (née Collier, granddaughter of Sir
Thomas Lunsford). In 1709, Spence attended school in Mortimer, near his birthplace, and later attended
Eton College and then
Winchester College. Spence matriculated to Magdalen Hall, Oxford on 11 April 1717, but did not go up until admitted as scholar or probationary fellow at
New College on 22 April 1720. On 30 April 1722, he received a full fellowship, taking his Bachelor of Arts degree on 9 March 1724 and Master of Arts on 2 November 1727. Spence was ordained in the
Oxford diocese on 5 June 1726. Early literary friends of Spence included fellow
Wykehamists Edward Rolle,
Robert Lowth,
Christopher Pitt, and
Edward Young. Spence wrote an essay on
Alexander Pope's translation of
Homer's
Odyssey in 1726 which gave rise to a friendship between Spence and Pope. In 1727 Pope published his comments on the second part of Spence's essay. == Later life ==