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Winnipeg Blue Bombers (first stint) Santos-Knox was signed by the
Winnipeg Blue Bombers after driving nine hours with his father to a tryout camp which his father had found in
Charlotte, North Carolina. He started his rookie season on special teams but by the end of the regular season was a starting linebacker and was being praised by coach
Mike O'Shea and media for big plays at big moments of games. After recording 10 tackles and 3 sacks against Toronto on July 27, 2018, Santos-Knox was named the CFL's third star of the week.
Edmonton Eskimos Santos-Knox spent the
2019 season with the
Edmonton Eskimos where he played in three regular season games. After the CFL canceled the
2020 season due to the
COVID-19 pandemic, he chose to opt-out of his contract with the
Edmonton Eskimos on August 27, 2020.
Hamilton Tiger-Cats On February 6, 2021, it was announced that Santos-Knox had signed with the
Hamilton Tiger-Cats.
Ottawa Redblacks On February 7, 2023, it was announced that Santos-Knox had signed with the
Ottawa Redblacks. He played in three seasons where he recorded 209 total tackles, five sacks, and two interceptions. He was released on January 30, 2026. ==References==