Wolfram was an
Amgen Scholar and she participated in a research at
Karolinska Institute in 2009 regarding a novel protein that increases the migration of cancer cells. The program solidified her desire to study translational cancer. She has been a visiting scholar at the Department of Molecular and Cellular Biology Research,
Sunnybrook Health Sciences Centre,
Toronto,
Canada, in 2010, investigating antiangiogenic receptor tyrosine kinase inhibitors. Wolfram began working as a research fellow for cancer and nanomedicine at the Houston Methodist Hospital in 2011. As she obtained her Ph.D. degree in 2016 she became a postdoctoral fellow. In 2017, she began holding affiliate faculty positions at the Houston Methodist's Department of Nanomedicine and at the
University of North Florida's Department of Biology. In the same year she also became as an Assistant Professor of Medicine at
Mayo Clinic, where she has been the director of the Nanomedicine and Extracellular Vesicles Laboratory until January 2022. Wolfram had come up with strategies for modulating the immune system to allow accurate drug delivery to tumors, particularly through the use of
chloroquine or through the body's own nanoparticles. In her
TED talk Wolfram notes that there are over 10 clinically approved nanoparticles for treating cancer. Despite her young age, she has already authored over 100 publications on nanoscale strategies for cancer and other life-threatening diseases, received more than 30 awards and given many important conference talks around the world. As of December 2025, she has an h-index of 53 and her work has been cited over 24,000 times. She was also named Finnish Expatriate of the Year in 2021. ==Other activities==