Domènec made his fortune in
Xàtiva, where he was involved in local commerce, specifically in the sugar trade. He was the son of
Domènec I de Borja and Caterina whose family name is not known. On 2 February 1375, Domènec de Borja, believed to be the father of Callixtus III, testified in a document as a citizen of Xàtiva. In 1404, Domènec was recorded as having been granted the title of
Sobreguarda of the frontiers of the
Kingdom of Castile by King
Martin of Aragon In 1408, Domènec's son, Alfons de Borja i Cavanilles (future Pope Callixtus III), granted his father the power to collect the pension of a censor in
Vall de Pego. ==Marriage and descendants==