Guanipa joined politics with
Rafael Caldera's presidential campaign in the
1983 presidential election, thereby entering the
Copei party. He was elected as a deputy to the Legislative Assembly of the Zulia State by Copei for the period 1994 to 1996, serving as President of the Legislation and Policy Commissions and as Vice President of the Sports, Recreation and Tourism and Regional Planning and Development Commissions. From February 1999 to March 2003, he served as General Director of the Regional Institute for Training and Sociopolitical and Sociocultural Studies for the Promotion of Man (IRFES), an institution located in Maracaibo, Zulia State. After the 1999 constitutional process, leaving Copei and from 2003 is part of Primero Justicia.
2017 regional elections Guanipa was a candidate for governor of his state, a place that got winning the primary election of officers of the Unit, facing the mayor of
Maracaibo, Eveling Trejo de Rosales on 10 September 2017. On 15 October 2017, during the regional elections, he was elected Governor of
Zulia state, declared the winner with 691,547 votes and 51.06%.
Arias Cárdenas, his opponent obtained 631,594 votes.
Dismissal as Governor of Zulia Guanipa was prevented from taking office after refusing to swear an oath before President Nicolás Maduro's National Constituent Assembly, which he considered illegitimate.
2018 presidential election On 26 January 2018, his brother and secretary general of Primero Justicia, Tomás Guanipa, communicated the possibility that Juan Pablo Guanipa was the party's presidential candidate – despite the fact that he could nominate
Henrique Capriles Radonski for the third time in future elections of the
Democratic Unity Roundtable (MUD) primaries. Guanipa declared in November 2017 would not rule out taking such responsibility within PJ and compete for the nomination of the opposition coalition. However, on 19 February 2018,
Justice First (PJ),
Democratic Action and
Popular Will (VP), announced they would not participate in presidential elections and expressed their rejection of the
National Electoral Council, ruling out any intention of Guanipa in the electoral race.
2020 Venezuelan National Assembly Delegated Committee election Alternate deputy of Guanipa, José Sánchez "Mazuco", announced in the day of the election that he was operated and hospitalized, so he would not be able to attend to the session, but assured that his vote would not make a difference since the main deputy Guanipa would attend instead. After being blocked from entering the
Palacio Federal Legislativo on 5 January 2020,
Juan Guaidó announced that a separate session of the
National Assembly would happen in the building of
El Nacional, a Venezuelan newspaper. National Assembly deputies signed their names on an attendance list upon entering the facility. Guanipa and were elected as first and second vice-presidents, respectively, taking oath at the scene. Several deputies abroad followed and endorsed the vote remotely from
Madrid, Spain. == 2025 arrest and detention ==