The 2012 Tour de San Luis was the 6th edition of the Tour de San Luis stage race. It was part of the 2011–12 UCI America Tour. Levi Leipheimer of Omega Pharma–Quick-Step won the race, mainly in the time-trial, which he won and where he made the difference with second placed Alberto Contador, who did win two mountain stages. With 2 stage wins for Francesco Chicchi and one for Tom Boonen, Omega Pharma–Quick-Step scored an impressive 4 wins out of 7. Italian Elia Viviani also managed to win one stage.