South Campus in
Laredo,
Texas. in Laredo was dedicated in September 2012, with
Governor Rick Perry and
Lieutenant Governor David Dewhurst in attendance. in east Laredo. Zaffirini has a 100 percent voting record, having through 2025 cast more than seventy-five thousand consecutive votes since January 1987. She even once missed her son's graduation to maintain the record. On January 9, 2007, Zaffirini became the second in seniority in the 31-member Texas Senate, of which she has been a member since 1987. In 2011, Zaffirini voted against the state appropriations bill because it reduced funding for public education by $5.4 billion, including $1.4 billion for targeted programs, such as pre-kindergarten expansion grants, one of her favorite programs. In 2013, Zaffirini will push for the issuance of tuition revenue bonds to fund capital construction projects on state college and university campuses, including TAMIU in Laredo. In 2012, Lieutenant Governor Dewhurst removed Zaffirini from the chairmanship of the Senate Committee on Higher Education in favor of
Kel Seliger, a Republican from
Amarillo. Instead Zaffirini chairs the Senate Committee on Government Organization. She will remain a member of the higher education committee under Seliger and will continue as the co-chair of the Oversight Committee on Higher Education Governance Excellence and Transparency. Zaffirini said that she will continue to influence higher education policy "but the only difference is that the gavel won't be in my hand." In July 2013, Zaffirini joined her Democratic colleagues in voting against Republican-sponsored legislation which passed the Senate, 19 to 11, to reduce from twenty-six to twenty weeks of gestation the maximum time limit during which a woman can procure an
abortion. Zaffirini, who is
anti-abortion, describes the new law as not anti-abortion, per se, but one that limits a woman's access to health care and fails to address the question of unintended
pregnancies. Zaffirini said that she does "not believe that an unborn child can feel pain at twenty weeks. Nevertheless that had nothing to do with my position. ..." On March 8, 2017, Zaffirini was the only dissenter in an eight-to-one vote of the Senate State Affairs Committee of the
bathroom bill, Senate Bill 6, introduced by her Republican colleague,
Lois Kolkhorst of
Brenham and strongly pushed by Lieutenant Governor
Dan Patrick, the Republican presiding officer of the Senate. The bill would require persons to use public restrooms corresponding to their genitalia at birth. Strongly opposed by business and athletic interests, the measure is now pending before the Texas House of Representatives. According to the Texas Senate, as of 2025, Zaffirini has helped pass over 1,400 bills, the most in state history. Zaffririni became the first female dean of the Texas Senate on December 30, 2023, when Sen.
John Whitmire resigned. ==Civil lawsuits==