In 1936 Comroe became an instructor at the Department of Pharmacology at the University of Pennsylvania's School of Medicine. He was promoted to Associate in 1940 and Assistant Professor in 1942. Between 1946 and 1957, Comroe continued to study breathing. With his colleagues, he developed scientific instrumentation and methods for evaluating human respiratory performance under normal conditions, while exercising, and during illness. Many of the
pulmonary function tests still used are based on this work. Comroe investigated topics including reflex control of breathing, rate and depth of breathing, and the effects of drugs and oxygen. He and
anesthesiologist Robert Dunning Dripps showed that the method of manual artificial respiration used at that time was inefficient, which eventually led to its replacement by
mouth-to-mouth resuscitation. Comroe was a founder of the
Institute of Medicine (later National Academy of Medicine). Comroe became a member of the
American Physiological Society in 1943, served on its council and committees, and was its president for 1960-1961. Comroe served on a number of national-level scientific advisory boards, including the National Advisory Heart Council, the Board of Scientific Counselors of the
National Heart Institute, and the National Advisory Mental Health Council. He expressed repeated dissatisfaction with its operations and public statements, and resigned in 1960. Comroe also served on national-level educational committees of the
American Society for Pharmacology and Experimental Therapeutics and the American Physiological Society. ==Books==