in 2007 to promote
The Mist|left Early in her career, Holden made a name for herself by co-starring opposite
Burt Reynolds in
Physical Evidence (1989),
Vanessa Redgrave in
Young Catherine (1991), and
William Shatner in the TV Movie
TekWar: TekLab (1994). She also played Mabel Dunham in the TV Movie
The Pathfinder (1996) (based on the novel of James Fenimore Cooper). Onstage, she starred in
Time and the Conways, written by
J. B. Priestley, and ''The Winter's Tale
, based on the play by William Shakespeare. Other stage roles include Regina in Ghosts
and Procne in The Love of the Nightingale
. After making various guest appearances on Due South, Murder, She Wrote, and Poltergeist: The Legacy (when she played a dual role), Holden found some success playing a recurring role on the seminal sci-fi series The X-Files: Marita Covarrubias, a mysterious government worker who becomes an informant to Special Agent Fox Mulder, from seasons four through nine (1996–2002). She also had a supporting role, as Mary Travis, opposite Michael Biehn and Ron Perlman, in the CBS TV series based on the MGM classic, The Magnificent Seven (1998–2000) and a role as Debra Campbell on Highlander: The Series''. Some of Holden's most notable roles include starring opposite
Jim Carrey in
Frank Darabont's film
The Majestic (2001) (It was while performing on stage in
Cat on a Hot Tin Roof, that Holden was discovered by Darabont). As Carrey's long lost love, she received critical acclaim for her performance. She also co-starred alongside
Dean Cain,
Jennifer Tilly, and
Tim Curry in the Canadian comedy ''
Bailey's Billion$''. Other movie roles have included those of
Michael Chiklis' character's former love interest in
Fantastic Four (2005), Cybil Bennett in Christophe Gans' artistic-horror video game adaptation of
Silent Hill (2006), Amanda Dumfries in
The Mist (2007). In 2008, she joined the final season of TV Series
The Shield, where she played Olivia Murray. From 2010 to 2013, she played the role of Andrea, a civil rights attorney and survivor of a global zombie plague in
The Walking Dead, an
AMC television
horror drama series. In 2013, she worked on the movie
Honeytrap as an executive producer. In 2014 she played the role of Ann McGinnis in the third season of
Major Crimes. Also in 2014, she co-starred in the movie
Dumb and Dumber To, opposite Jim Carrey,
Jeff Daniels and
Kathleen Turner. She played Adele Pinchelow, the main antagonist of the
Farrelly brothers comedy. In 2015, she appeared as Dr. Hannah Tramble, an ER surgeon, in the third season of
Chicago Fire. It was announced Holden would reprise her role as Dr. Tramble in a planned spinoff,
Chicago Med. Holden was set to co-star opposite
S. Epatha Merkerson and
Yaya DaCosta in the ensemble medical drama. The series is being conceived and written by
Chicago Fire creators/executive producers
Derek Haas and
Michael Brandt. However, she dropped out of the project for "family reasons". In 2016, she appeared in
The Abolitionists, a documentary film by
Darrin Fletcher. In 2017, Holden joins the cast of
The Americans in the fifth season, when she plays Renee. She was cast in indie thriller
Pyewacket, a movie directed by
Adam MacDonald. In 2018, Laurie Holden appeared in the crime thriller
Dragged Across Concrete, starring
Mel Gibson and
Vince Vaughn. Holden joined the cast of American
legal drama television series
Proven Innocent (which premiered in 2019 on
Fox), where she plays Greta Bellows. In 2022, she joins
The Boys season 3, in the role of Crimson Countess, while also performing the songs "America's Son" and "Chimps Don't Cry". == Charity work and human rights activism ==