Alkanolamine

1-Aminoalcohols are better known as hemiaminals. Methanolamine is the simplest member. 1-Aminoalcohols tend to be labile, readily converting to more highly condensed derivatives or hydrolyzing to the amine and carbonyl. ==2-Aminoalcohols==

Routes 2-Aminoalcohols are often generated by the reaction of amines with epoxides: : Hydrogenation or reduction of amino acids gives a large family of chiral 2-aminoalcohols: : Examples include prolinol (from proline), valinol (from valine), tyrosinol (from tyrosine). Some 2-aminoalcohols are produced by the Sharpless asymmetric amino hydroxylation. Uses and examples Simple alkanolamines are used as solvents, synthetic intermediates, and high-boiling bases. 2-Aminoalcohols have been used as synthetic building blocks and chiral auxiliaries.Amino ethanols have been proven to be vital precursors for chiral morpholines and piperazines. Key members: ethanolamine, dimethylethanolamine, N-methylethanolamine, Aminomethyl propanol. Two popular drugs, often called alkanolamine beta blockers, are members of this structural class: propranolol, pindolol. 2-Aminoalcohols can also be found in the direct action subgroup of adrenergic drugs such as epinephrine, isoproterenol, phenylephrine and isoetarine. Other medicinally useful derivative of ethanolamine: Isoetarine, veratridine, veratrine, epinephrine (adrenaline), norepinephrine (noradrenaline), atropine. == 1,3- to 1,7-amino alcohols ==

Two examples of longer aminoalcohols include Heptaminol, a cardiac stimulant, and propanolamines. 1,3-Aminoalcohols are present in several bioactive molecules, such as Sedinone, Dumetorine, and Hygroline. 1,3-Aminoalcohols have be synthesize through a couple methods. Similar to 2-aminoalcohols, 1,3 aminoalcohols can be formed through ring openings, such as an azo-ring opening and addition. Catalyzed alkylation of primary amines with 1,4-butanediol is another synthetic route for 1,4-aminoalcohols. ==References==