Along with his twin brother
Kamanawa, Kameeiamoku's parents were the
keiki aliʻi (prince or child of a chief),
Keawepoepoe and Kanoena (w). As the son of Kalanikauleleiaiwi and Lonoikahaupu, monarch's of several kingdoms between them, Keawepoepoe was an
aliʻi (noble) of Hawaii, Maui, Oahu and Kauai. As well being an
aliʻi nui (great king or supreme monarch) Lonoikahaupu was a kahuna (priest) of the order of Lono (order of Nahulu or Holoa'e), one of two priestly orders, Kū (Kuali'i or Kauali'i) being the other. Through this union Keawepoepoe received the
kapu o pahenakalani (the prostrating kapu) which is how the Hawaii
aliʻi received the
kapu (a religious code of conduct) called the
kapu moe.
Fornander identifies their mother, Kanoena, as the daughter of Lonoanahulu from the Ehu
ohana (family). Almira Hollander Pitman refers to Kanoena in 1931 as Keawepoepoe's cousin. However, in the Hawaiian Genealogy book volume 44:
"Eia ka lani ke koi pae moku ka lauhulu paoki o ka aina", it shows Lonoanahulu marrying Hikuakanaloauuoo and having Manohili who marries Halao, which is the couple that has Kanoena. That would make Lonoanahulua Kanoena's grandfather.
Kamakau lists Mano-hili as one of the men who assisted Kameʻeiamoku in his attack on the
Fair American. Fornander also refers to Lonoanahulu, along with the Kameʻeiamoku and Kamanawa in regards to lands passed down to them from
Liloa; == The Metcalfes, the Eleanora and the Fair American ==