Karamo was most known for his television debut on the
MTV reality series
The Real World: Philadelphia in 2004. Brown was a contributing host on
HLN's
Dr. Drew On Call, YouTube's
The Young Turks, Brown hosted MTV's
Are You the One? Second Chances. Brown is the culture expert in the Netflix revival of
Queer Eye. The first season was released on
Netflix in February 2018. In June 2019, Brown had a cameo role in
Taylor Swift's "
You Need to Calm Down" music video, along with a long list of other celebrities. In 2019 Brown competed on the
28th season of celebrity dance competition
Dancing with the Stars. He was paired with professional dancer
Jenna Johnson. Brown and Johnson were the fourth couple eliminated. Brown publicly defended his fellow contestant, former Trump White House press secretary
Sean Spicer, who was seen as a divisive and controversial choice for the show. Brown called Spicer "a good guy" and "a friend," and said that he "was proud of him," but also said he did not appreciate Spicer serving as a mouthpiece for
many lies in service of Trump. Brown was criticized by many, including author
Roxane Gay for normalizing Spicer and his work in the White House. Brown's trailer at
DWTS shared a wall with Spicer's; Brown intentionally had transgender friends over, and invited Spicer to socialize. Starting in 2018, Brown shared some of his best advice about promoting self-esteem to students at multiple universities. In November 2019, Brown published a children's book,
I Am Perfectly Designed, written with his son Jason "Rachel" Brown, illustrated by Anoosha Syed, and published by
Henry Holt and Company. Jason said that the title of the book is a phrase Brown often said to Jason growing up. In 2020, Karamo Brown teamed up with Honest Company alumni to create MANTL, a premium personal care brand for bald and or balding men. In 2020, Brown was named to the
Ebony Power 100 List. He judged an episode of
Is It Cake?, which premiered on Netflix in March 2022. Brown guest-hosted several episodes of
Maury in the 2021–22 season. In March 2022, Brown was announced as host
Maury Povich's successor; Povich retired and Brown hosted a new talk show for
NBCUniversal Television Distribution, with
Karamo starting recording in August and premiering September 19. In September 2022, Brown featured TikToker creators Chef Pii and Allured Beauty on the Karamo Show in response to Allured Beauty's discovery that Pii's Pink Sauce product was not safe for human consumption after getting it tested by a lab. Her discovery came after multiple similar accounts from other consumers. Brown received backlash for defending Chef Pii and criticizing Allured Beauty, with viewers pointing out that he was 'gaslighting' Allured Beauty during the episode. In February 2023, Brown released a follow-up segment in which he apologized to Alle for how the original "Pink Sauce" episode had been handled. == Activism ==