The club was founded on Tuesday October 1, 2013, when the former Metropolitan Sporting Club changed its name to Karela United Football Club. Karela initially competed in the Ghana Division One league, off which they emerged as champions and were subsequently promoted into the Ghana Premier League in the year 2017. The first official match was played on Saturday November 23, 2013 against Proud United in a goalless draw at
Kasoa.
2018 – present After the Ghana Premier League was hit by the
Anas Number 12 scandal and the
2018 league season was cancelled along with the
dissolution of the Ghana Football Association in June 2018, a Normalisation Competition was organised by the GFA normalisation committee to be played in place of the main league as the restructuring of the GFA was being put in place. Karela placed 2nd in group B to qualify for the next stage, beating
Ashanti Gold SC at that stage to qualify to the finals to play against
Asante Kotoko. Karela lost the finals in a penalty shootout round after the match ended in a 1–1 draw. They lost the bid to represent Ghana at the
2019–20 CAF Champions League and were declared runner-up in the
Tier 1 of the competition. After several distractions to the Ghana premier league from 2017 due to the dissolution of the GFA in June 2018, the
2018 league season was abandoned and the uprising of the deadly
COVID-19 pandemic which also caused the 2019–20 league to be cancelled abruptly, the
2020–2021 season started in November 2020. == Rivalry ==