Karlis' first research, conducted in the 1940s, was inspired by the work of English physicist and parapsychologist
William F. Barrett, specifically his book,
Death Bed Visions. In an attempt to build on Barrett's research, he and
Erlendur Haraldsson conducted a four-year study whereby they sent out hundreds of questionnaires to doctors and nurses in both the US and northern India, asking them about their observations regarding dying patients. Their research highlighted differences between cultural experiences near death. They found that a person's religion greatly influenced what was seen and that this was most apparent when observing the differences between Indian and American experience where Indian patients were far more likely to see a personification of death than Americans. Despite the far smaller pool of data (the newer study involved just 877 doctors in the USA alone), Osis concluded to his satisfaction that what he called the
"sick brain hypothesis" – that the decrease of brain activity was causally linked to near death experiences – did not stand up to scrutiny. In 1957, Osis became the director of the
Parapsychology Foundation in New York, being elected as president in 1961. In 1971, he and Haraldsson co-authored the book
At the Hour of Death, describing the results of their research. ==Alex Tanous==