Yelick served from 2008 to 2012 as the director of the
National Energy Research Scientific Computing Center (NERSC), the scientific computing center that provides high-performance computing facilities and associated expertise to over 9,000 scientists supported by the U.S. Department of Energy Office of Science. In 2010, she was appointed the Associate Laboratory Director for Computing Sciences at
Berkeley Lab, overseeing NERSC, the high-speed research network
Energy Sciences Network (ESnet), and the Computing Research Division. In this role she managed an organization with a research budget of about $150 million. In her role as associate laboratory director, Yelick led the development of the 2019 Computing Sciences Strategic Plan for Berkeley Lab. In the introduction to that plan, she said: She also led a major initiative, Machine Learning (ML) for Science, in which researchers developed advanced machine learning tools to accelerate discovery in a wide range of scientific disciplines. In 2021, Yelick delivered the inaugural lecture in the distinguished lecture series at the Harvard Institute for Applied Computational Science, with the title "Machine Learning in Science: Applications, Algorithms, and Architectures." Since 2021, Yelick has served as the vice chancellor for research (VCR) at the University of California, Berkeley. In this role, she provides the primary leadership in research policy, planning, and administration, and also leads university-industry relations, research compliance, research communications, and federal research development. The VCR supervises over fifty campus research units, twelve research museums and remote field stations, and the research administration offices. The research enterprise at UC Berkeley attracted $965 million in extramural support in the fiscal year ending June 30, 2025. ==Awards and honors==