In 1998, as the
Raccoon City incident begins, the
Umbrella Corporation hires a private military firm to help evacuate high-ranking Umbrella executives and government officials. The firm deploys Unit 6, but the majority are bitten by zombies; surviving members JJ and Dylan Blake contact headquarters to seek extraction and medical assistance, but are instructed to quarantine and ultimately eliminate their fellow comrades, leaving JJ in disbelief and angering Dylan. The pair argue until the infected soldiers attack them and bite JJ, forcing Dylan to kill him. Seventeen years later in 2015, Field Operations Support (FOS) Agent
Ingrid Hunnigan tasks Division of Security Operations (DSO) agent
Leon S. Kennedy with apprehending
DARPA researcher and robotics engineer Doctor Antonio Taylor in
San Francisco for selling classified information to foreign powers. During the briefing, Leon learns Taylor was being hunted by the
San Francisco Police Department, but was kidnapped by unidentified assailants in a van. Recognizing the van as it passes him, Leon tries to intercept them, but is thwarted by Maria Gomez, a criminal who survived their last encounter the year prior. Meanwhile, Bioterrorism Security Assessment Alliance (BSAA) advisor
Rebecca Chambers informs Agent
Chris Redfield of twelve deaths from an advanced strain of the T-virus, seemingly forcibly injected into the victims. Chris visits his partner
Jill Valentine, hoping to stop her from taking part in the operation due to her time under
Albert Wesker's mind control and subsequent mental health issues, but she refuses. Chris and Jill meet with Rebecca and Chris's sister
Claire Redfield to discuss their findings, during which Claire notes her discovery of an orca infected with the same advanced T-virus strain swimming near the
Greater Farallones National Marine Sanctuary, which had also happened to several missing whales. Discovering that all of the human victims had visited
Alcatraz Island before they died, Jill and the Redfields travel there posing as tourists, but are separated when it is stricken by a sudden zombie outbreak. While exploring the sewers, Jill encounters Leon and joins him in fending off a new form of
Lickers before eventually reaching the armory, where they find blueprints for mosquito-like
drones used to
infect people with the virus. However, they are captured by Dylan and thrown into a prison cell with Taylor and the Redfields. Believing there is no justice in the world, Dylan uses the drones to infect the Redfields and Leon, sparing Jill so she can witness her friends die like how he was forced to watch his team die in Raccoon City. He then reveals that he has taken over arms dealer Glenn Arias' crime syndicate and joined forces with Maria, who seeks revenge for her father Diego's death, before fatally shooting Taylor and escaping to use his drones around the world. As he dies, Taylor gives Claire a code for controlling the drones. While Jill pursues Dylan, she encounters Rebecca, who prepares a vaccine for the group and cures them. Leon pursues Maria and kills her after a brutal confrontation. The Redfields, Jill, Leon, and Rebecca regroup to fight Dylan in the final battle, who merges himself with a bio-organic weapon and overpowers the group. Claire and Rebecca take control of Dylan's drones and program them to infect him and weakening him enough for Jill, Leon, and Chris to kill him with
explosive weaponry. As the group awaits BSAA rescue helicopters, Chris praises Jill's heroism. ==Voice cast==