Tampa Bay Buccaneers After going undrafted in the
1995 NFL draft, Holcomb signed with the
Tampa Bay Buccaneers on May 1, 1995. He was released on August 22, signed to the team's practice squad on August 29, released again on September 19, signed to the practice squad again on October 4, released for the third time on October 17, and signed to the practice squad for the third time on December 19, 1995. Holcomb was released by the Buccaneers for the final time on August 19, 1996, as the team opted to go with
Scott Milanovich as the No. 3 quarterback. In January 2003, Holcomb started in place of an injured Couch in the
Wild Card round against the
Pittsburgh Steelers. Holcomb became the third quarterback in playoff history to throw for more than 400 yards. He finished the game with 429 yards, a new postseason record for a regulation game, but Cleveland lost 36–33. In 2003, Holcomb's third season, he had more playing time playing ten games and starting eight of them. He replaced Couch as starting quarterback during that season. Overall in 2003, he threw ten touchdowns and twelve interceptions. In his final season as a Brown
Jeff Garcia replaced him as starting quarterback. Holcomb only played in four games and started two of them in which he threw seven touchdowns and five interceptions with 737 yards passing.
Buffalo Bills Holcomb went to the
Buffalo Bills before the 2005 season. He started half of the games in his first season as a Bill while
J. P. Losman started the other half. Holcomb threw ten touchdowns and eight interceptions with 1,509 passing yards that season. In Holcomb's second and final season as a Bill he didn't play a regular season game the whole season.
Philadelphia Eagles Holcomb was traded on March 26, 2007, to the
Philadelphia Eagles with
Takeo Spikes for
Darwin Walker and a conditional
2008 draft pick, which the Bills would use to select
Stevie Johnson.
Minnesota Vikings On August 27, 2007, the Eagles traded Holcomb to the
Minnesota Vikings for a sixth round pick in the
2009 NFL draft. Holcomb played and started three games that season throwing two touchdowns and an interception with 515 passing yards. After the 2007 season, the Vikings went on to release him on February 27, 2008. On July 7, 2008, it was announced that Holcomb would retire from the NFL. ==Broadcasting career/post-playing career==