WNBA Indiana Fever (2018–present) Mitchell was the second overall pick in the
2018 WNBA draft by the
Indiana Fever, and was selected to the 2018
WNBA All-Rookie Team alongside
A'ja Wilson,
Ariel Atkins, and
Diamond DeShields. Mitchell participated in the
WNBA Three-Point Contest in 2018 and 2023. For her leadership on and off the court, Mitchell was awarded the 2023
Dawn Staley Community Leadership Award, becoming the 4th Fever player to win the recognition after
Tamika Catchings (2008 & 2016) and
Natalie Achonwa (2020). Mitchell participated in the 2024 Skills Challenge at
2024 WNBA All-Star Weekend after Fever teammate,
Erica Wheeler, was unable to attend due to the
global computer outages delaying her travel. She became a three-time
WNBA All-Star with appearances in
2023,
2024 and
2025 alongside Fever teammates
Aliyah Boston and
Caitlin Clark. After entering free agency in 2025, the Fever designated Mitchell as a core player, giving the team exclusive rights and guaranteeing her a supermax contract for the 2025 season. Mitchell had been the team's top signing priority according to Fever GM
Amber Cox. Mitchell signed a core contract on January 29. During the 2025 WNBA season, Mitchell experienced a serious medical incident in Game 5 of the semifinals on September 30, 2025. Initially believed to be severe lower-body cramping, it was later identified as rhabdomyolysis—a dangerous condition in which muscle tissue breaks down and releases harmful proteins into the bloodstream. She was transported to a local Las Vegas hospital to receive IV fluids and was released later that night.
Overseas In 2019, Mitchell played for Egyptian club
Al Ahly in the 2019
FIBA Africa Women's Clubs Champions Cup. Mitchell played in
Israeli League for
Elitzur Ramla in the 2021–22 off-season. In 2023, Mitchel played 8 games with
Uni Girona in
Girona,
Spain in the
Spanish First League and 5 games in
EuroCup. Mitchell signed with the
Shanxi Flame of the
Women's Chinese Basketball Association for the 2024–2025 season.
Unrivaled On November 5, 2025, it was announced that Mitchell had been drafted by
Hive BC for the
2026 Unrivaled season. ==Personal life==