Kentucky Route 146 is a 33.505-mile-long (53.921 km) state highway in Kentucky that runs from U.S. Route 60 in the St. Matthews suburb of Louisville to U.S. Route 421, Kentucky Route 55, and Kentucky Route 573 in New Castle via Lyndon, Anchorage, Pewee Valley, Crestwood, Buckner, La Grange, and Pendleton. The route generally follows the Cincinnati-Louisville CSX Transportation rail line, crossing the line once in Lyndon, twice in Anchorage, once at its intersection with Kentucky Route 22 in Crestwood, and once approximately 0.7 miles (1.1 km) east of the Henry/Oldham county line between La Grange and Pendleton. There are no low clearances along the entirety of the mostly two-lane route. The route is rather smartly designed as it carries traffic from Henry County to the east end of Louisville, KY. Interstate 71 exit 28 routes to KY 146 in Buckner. Its speed limit is 55 mph (89 km/h) in the rural parts and 35 mph (56 km/h) in the city limits.