Ethnikos Neo Keramidi made its first appearance in a national category during the
2020–21 season, securing a 3rd-place finish in its group with 25 points. The team played only the first round of matches due to disruptions caused by the
COVID-19 pandemic. The
following season proved challenging, with the team barely avoiding relegation by a single point. In subsequent seasons, Ethnikos Neo Keramidi established itself as a formidable force in the Gamma Ethniki, boasting a strong squad. In February 2023, the club appointed
Vangelis Moras, a former international footballer and coach of
Apollon Larissa and
P.O. Elassona, as its head coach. The
2023–24 season marked the most successful in the club's history. Ethnikos Neo Keramidi won their Gamma Ethniki group and achieved automatic promotion to
Super League Greece 2, the second division of Greek football. == Honours ==