Keratin-10 is a member of the type I (acidic) cytokeratin family, which belongs to the superfamily of
intermediate filament (IF) proteins. Keratins are heteropolymeric structural proteins which form the intermediate filament. These filaments, along with
actin microfilaments and
microtubules, compose the
cytoskeleton of
epithelial cells. Mutations in this gene are associated with
epidermolytic hyperkeratosis. This gene is located within a cluster of keratin family members on chromosome 17q21. ==Interactions==