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Keratosis pilaris

Keratosis pilaris is a common, autosomal-dominant, genetic condition of the skin's hair follicles characterized by the appearance of possibly itchy, small, gooseflesh-like bumps, with varying degrees of reddening or inflammation. It most often appears on the outer sides of the upper arms, thighs, face, back, and buttocks; KP can also occur on the hands, and tops of legs, sides, or any body part except glabrous (hairless) skin. Often the lesions can appear on the face, which may be mistaken for acne or folliculitis.

Signs and symptoms
KP results in small, rough bumps on the skin's surface. They are skin-colored bumps the size of a grain of sand, many of which are slightly pink in light-skinned people and dark spots in dark-skinned people. The symptoms may also worsen during pregnancy or after childbirth. Increased sun exposure might mitigate the symptoms of KP. ==Pathophysiology==
Pathophysiology
KP occurs when the human body produces excess amounts of the skin protein keratin, resulting in the formation of small, raised bumps in the skin, often with surrounding redness. The excess keratin, which is the same color as the person's natural skin tone, surrounds and entraps the hair follicles in the pore. This causes the formation of hard plugs (a process known as hyperkeratinization). Many KP bumps contain an ingrown hair that has coiled. This is a result of the keratinized skin's "capping off" the hair follicle, preventing the hair from exiting. The hair grows encapsulated inside the follicle. KP is more common in patients with atopic diseases such as allergic rhinitis and atopic dermatitis. KP subtypes are occasionally part of genetically inherited syndromes associated with intellectual disability, neuro-cardio-facial-cutaneous syndromes, RASopathies, ectodermal dysplasias, and certain myopathies. ==Diagnosis==
Diagnosis
Physicians can often diagnose KP simply by examining the skin without specialized tests, Those with this condition are generally encouraged to contact a physician if the bumps are bothersome and do not improve with over-the-counter lotions. Classification The several different types of KP include KP rubra (red, inflamed bumps, which can be on arms, head, legs), KP alba (rough, bumpy skin with no irritation), KP rubra faceii (reddish rash on the cheeks), KP atrophicans, keratosis follicularis spinulosa decalvans, atrophoderma vermiculatum, KP atrophicans faciei, erythromelanosis follicularis faciei et colli, and papular profuse precocious KP. It is not related to goose bumps, which result from muscle contractions, except that both occur in the area where the hair shaft exits the skin. ==Gallery==
Gallery
File:Keratosis Pilaris on Back.jpg|Keratosis Pilaris on Back File:Keratosis Pilaris on Lower Extremity.jpg|Keratosis pilaris on lower extremity File:KeratosisPilaris.jpg|Keratosis pilaris on the back of the upper arm File:Keratosis pilaris arm.jpg|Keratosis pilaris on arm File:Keratosis pilaris skin plugs.jpg|Skin plugs removed from a person with keratosis pilaris ==Treatment==
Treatment
Topical creams and lotions are currently the most commonly used treatment for KP, specifically those consisting of moisturizing or keratolytic treatments, including urea, lactic acid, glycolic acid, salicylic acid, vitamin D, fish oil, or topical retinoids such as tretinoin. Many products are available that apply abrasive materials, with alpha or beta hydroxy acids to assist with exfoliation. Some cases of KP have been successfully treated with laser therapy, which involves passing intense bursts of light into targeted areas of the skin. Depending on the body's response to the treatment, multiple sessions over the course of a few months may be necessary. ==Epidemiology==
Epidemiology
Worldwide, KP affects an estimated 30 to 50% of the adult population, and around 50 to 80% of all adolescents. It is more common in women than in men. It is often present in otherwise healthy individuals. The skin condition is prevalent in people of all ethnicities, and no particular ethnicity is at higher risk for developing KP. Although KP may manifest in people of any age, it usually appears within the first decade of life and is more common in young children. In most cases, the condition gradually improves before age 30, but it can persist longer. ==See also==
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