Cassese's coaching career began at
Stony Brook University on August 31, 2004 when he was the first assistant hired by
Lars Tiffany who had been appointed head coach three weeks earlier. He directed an extra-man offense which led the
NCAA Division I with a 45.7 percent efficiency rate in his only campaign with the 10–6 Seawolves in 2005. He was named interim head coach on June 5, 2006, two months after Pressler resigned amidst a
criminal case involving the program. He resumed his assistant duties weeks later when
John Danowski became head coach on July 21. The Blue Devils had a 23–5 overall record and were a
2007 NCAA Division I finalist in his two years with its coaching staff. Cassese was appointed as head coach at
Lehigh University on July 5, 2007, succeeding
Chris Wakely who had relinquished his duties a month earlier because of
multiple sclerosis. His 136–104 overall record and .567 winning percentage in sixteen seasons with the Mountain Hawks both rank as the best in program history. His teams played in six
Patriot League championship games, winning twice in 2012 and 2013 and earning a third automatic bid to the NCAA Championships in
2021. The Mountain Hawks were also the only team to qualify for twelve consecutive Patriot League Tournaments during the last thirteen years of Cassese's tenure at Lehigh. Cassese was reunited with Tiffany as associate head coach/offensive coordinator at the
University of Virginia on June 20, 2023. ==Awards==