Nelson was selected by the
Tampa Bay Buccaneers in the fourth round, 107th overall, of the
2019 NFL draft. In Week 16 of the 2020 season against the
Detroit Lions, Nelson recorded his first career sack on
David Blough during the 47–7 win. Nelson was a part of the
Super Bowl LV champion Buccaneers. He recorded four solo tackles across the postseason, including one in the Super Bowl. On March 16, 2023, Nelson signed a two-year contract extension with the Buccaneers. On March 11, 2025, Nelson re-signed with Tampa Bay on a two-year, $10 million contract. In Week 8, Nelson intercepted a pass from
Spencer Rattler and returned it for a three-yard touchdown. He also recorded two sacks and a forced fumble in the 23-3 win over the
New Orleans Saints, earning NFC Defensive Player of the Week. ==Career statistics==