Seattle Seahawks Pierre-Louis was selected by the
Seattle Seahawks in the fourth round (132nd overall) of the
2014 NFL draft. Pierre-Louis made his NFL debut on September 21, 2014, in an overtime win against the
Denver Broncos where he recorded one tackle. Pierre-Louis was placed on season-ending
injured reserve for a shoulder injury. He finished the season with 10 tackles in seven games.
Kansas City Chiefs On July 28, 2017, Pierre-Louis was traded to the
Kansas City Chiefs in exchange for
D. J. Alexander.
New York Jets On March 17, 2018, Pierre-Louis signed a two-year contract with the
New York Jets. On August 11, Pierre-Louis was suspended the first game of the 2018 season for violating the NFL's Policy and Program for Substances of Abuse. He played in nine games before being placed on injured reserve on December 29. On February 19, 2019, the Jets declined the option on Pierre-Louis' contract, making him a free agent.
Chicago Bears On May 8, 2019, Pierre-Louis signed a one-year contract with the
Chicago Bears. In Week 16 against the Chiefs, Pierre-Louis recorded a team-high 12 tackles during the 26–3 loss. The following week against the
Minnesota Vikings, Pierre-Louis recorded his first career interception off a pass thrown by quarterback
Sean Mannion during a 21–19 win.
Washington Redskins / Football Team Pierre-Louis signed a one-year contract with the
Washington Redskins on March 31, 2020. The team's name was changed to the Washington Football Team later in the offseason.
Houston Texans On March 16, 2021, Pierre-Louis signed a two-year contract worth up to $8 million with the
Houston Texans. He was placed on injured reserve on September 16 with a hamstring injury. He was activated on October 23. On August 30, 2022, Pierre-Louis was waived by the Texans and signed to the
practice squad the next day. He was promoted to the active roster on September 10. He suffered a groin injury in Week 2 and was placed on injured reserve on September 20. ==NFL career statistics==