Miami Dolphins Vickerson was selected by former Miami Dolphins head coach
Nick Saban with a seventh-round pick (216th overall) in the
2005 NFL draft. After being late for numerous team meetings the Dolphins considered pulling their contract offer from the table, however he was signed on July 24. After spending two days on the Active/Non-Football Injury list, Vickerson was cleared to practice. After compiling five tackles and a sack in preseason, Vickerson appeared likely to make the team. However, he was placed on Injured Reserve after suffering an ACL injury in a preseason game against the
Atlanta Falcons on September 1. Vickerson was on the bubble to make the team in 2006 and was rumored to be a candidate for the trading block, but in the end did make the final roster. He was inactive for all 16 contests in 2006, and after two seasons had never appeared in a regular season game for the Dolphins. Vickerson became an unrestricted free agent on March 2, 2007, after the Dolphins declined to offer him a contract as an exclusive rights free agent. He was re-signed by the team and allocated to
NFL Europa on March 9. In 10 starts for the
Cologne Centurions, Vickerson recorded 31 tackles, 3.5 sacks and two passes defensed. He was named to the 2007 All-NFL Europa team. Despite Vickerson's strong performance in NFL Europa, he was released by the Dolphins on August 27.
Tennessee Titans Vickerson had a workout with the
San Francisco 49ers on September 6, 2007, but was not signed. On November 1, he was signed to the
practice squad of the
Tennessee Titans - the team with which his brother Quartez attended training camp. On November 28, Vickerson was promoted from the practice squad to the active roster after defensive tackle
Demetrin Veal was released. He made his NFL debut on December 2, recording two assisted tackles in the team's 28–20 win over the
Houston Texans.
Seattle Seahawks Vickerson was traded to the
Seattle Seahawks with
LenDale White a fourth (111) and fifth (185) round pick in the
2010 NFL draft for a fourth (104) and fifth (176) round pick in the
2010 NFL draft. Vickerson was released before the start of the regular season on September 5, 2010.
Denver Broncos Vickerson was signed by the
Denver Broncos on September 7, 2010. On November 16, 2012, Vickerson was fined $15,000 for horse-collar tackling
Carolina Panthers quarterback
Cam Newton in Week 10. Vickerson came under scrutiny in a highly anticipated Sunday Night Football game against the
Indianapolis Colts with his three personal fouls and hit on
Samson Satele, knocking Satele out of the game with a knee injury. The Broncos would go on to lose 39-33 for their first loss of the season after starting 6–0. Vickerson was released by the Broncos on August 30, 2014.
Kansas City Chiefs On September 9, 2014, Vickerson was signed by the
Kansas City Chiefs.
New York Jets Vickerson was signed by the
New York Jets on March 24, 2015. ==NFL career statistics==