Among the museum's exhibits include correspondence, uniforms and furniture, in addition to exhibits on snakes and animals native to Africa. and ethnographic artifacts from Bangwato merafe, which date back to the time of Khaima III. The museum also has artifacts about the culture of the
San people and the museum contains temporary art displays. In addition, the museum has also preserved historical Botswana uniforms. The museum contains photographs of the funeral of Botswana's first president, Seretse Khama, and archives about the Khama family. After writer
Bessie Head's death, the museum acquired several of her papers, including notes and sketches as well as writings. In 2006, Bessie Head's room was installed in the museum, as well as permanent exhibits about the writer. In July 2013, the Bessie Head Society in collaboration with the museum organized a symposium in Serowe to commemorate the anniversary of the publication of Bessie's book,
A Question of Power. In November 2020, the museum opened 'Then we were Bechuana', a display of late 19th-century items, curated by Scobie Lekhutile and Gase Kediseng. The display featured digitised images of items in
Brighton Museum. The real items were intended to have been displayed through an international loan but this had not been possible because of the
COVID-19 pandemic. In 2026,
Brighton and Hove Museums announced the
repatriation of 45 objects to the Khama III Memorial Museum. The items from the
Gammangwato region had been acquired by a
missionary who had worked with
Khama III and were lent to
Brighton Museum in 1899 before being donated in 1936. A
cultural festival was planned to celebrate the repatriation and Botswana's creativity and history. == International connections ==