Khawaja Saad Rafique started his political career as a student leader representing Muslim Student Federation, from MAO College Lahore in early 1980s, and later on joined the PML-N. In the
1997 Pakistani general elections, Rafique participated in the elections on the PML-N's ticket and was elected as the member of
Provincial Assembly of the Punjab for the first time. He was appointed Special Assistant to Prime Minister for Youth Affairs by then Prime Minister of Pakistan Nawaz Sharif, but his tenure was terminated by General
Pervez Musharraf after the latter's
1999 Pakistani coup d'état. He was among the PML-N leaders who confronted Musharraf in the absence of Nawaz Sharif. During the period, he served as president of PML-N Punjab. He was eventually arrested and imprisoned after calling for
Musharraf's removal. He, along with party colleagues and lawyers, took to the streets calling for the resignation of Musharraf and the reinstatement of judges deposed by him. He was also put behind bars for partaking in violent protests for the said purpose. Among
PML-N's leaders, Rafique was one of the activists who kept the PML-N alive during the Musharraf government. In June 2013, Rafique was appointed
Minister of Railways by the
Prime Minister Nawaz Sharif and took
oath on 8 June 2013. He had ceased to hold ministerial office in July 2017 when the federal cabinet was disbanded following the resignation of Prime Minister
Nawaz Sharif after
Panama Papers case decision. Following the election of
Shahid Khaqan Abbasi as Prime Minister of Pakistan, Rafique was inducted into the federal cabinet of Abbasi and was appointed Minister for Railways for the second time. Upon the dissolution of the National Assembly on the expiration of its term on 31 May 2018, Rafique ceased to hold the office as Federal Minister for Railways. He was re-elected to the Provincial Assembly of Punjab as a candidate of PML-N from Constituency PP-168 (Lahore-XXV) in the
2018 Pakistani general election. Rafique also ran for the seat of the National Assembly from Constituency NA-131 (Lahore-IX) but was unsuccessful as he was defeated by Prime minister Imran Khan along with 4 other seats from which he won in general election of 2018. He was re-elected to the National Assembly as a candidate of PML-N from Constituency NA-131 (Lahore-IX) in the by-election held on 14 October 2018 after Imran Khan resigned from this seat and kept his home-city seat of Mianwali. After the removal of Prime Minister Imran Khan through the vote of no confidence Khawaja Saad Rafique was made Railway Minister in Shehbaz Sharif's Cabinet. Rafique was defeated by
Latif Khosa in the General Election held on 8 February 2024. == Personal life ==