K. senegalensis has been extensively studied for
trypanocidal activity. Atawodi et al 2003, Wurochekke and Nok 2004, Mikail 2009, Aderbauer et al 2008, Umar et al 2010, Adeiza et al 2010, Ibrahim et al 2008, and Ibrahim et al 2013a investigate
extracts of
stem bark both in vitro and in vivo in rats, against
T. evansi,
T. congolense and
T. b. brucei. All showed promising results and a few demonstrated an effective dose. The wood is used for a variety of purposes. It is often used conventionally for carpentry, interior trim, and construction. Traditionally the wood was used for
dugout canoes, household implements,
djembe, and fuel wood. The bitter tasting bark is used for a variety of medical purposes; it is taken against fever caused by malaria, stomach complaints, and headaches. It is applied externally to cure skin rashes, wounds, or any abnormality. Ethnobotanical and ethnopharmacological literature has reported use of
Khaya senegalensis stem bark in women's reproductive health contexts, including for irregular menstruation. A 2025 randomised, double-blind, placebo-controlled trial (
n=84) evaluated a
Khaya senegalensis preparation in women experiencing menstrual pain and reported reductions in daily pain ratings and menstrual distress over one menstrual cycle compared with placebo. It has been exported from West Africa (Gambia) to Europe since the first half of the 19th century and has been exploited heavily for its timber. It is now used more locally, and is planted ornamentally as a roadside tree. ==Conservation and threats==