5...Nf6 is the most common reply, attacking White's weak pawn on e4 and exerting control over central squares. White almost always responds with 6.Bc4, 6.Nxg4, or 6.d4. 6.Nxg4 is relatively drawish compared to the other options.
6.Bc4 The line most often continues 6...d5 7.exd5 Bd6 8.d4 Nh5 which is also known as the Anderssen Defense and is considered the main line of the Kieseritzky Gambit itself. After 9.0-0 Qxh4 10.Qe1 Qxe1 11.Rxe1 the position is approximately equal. A relatively untested try is 9.Nc3!?, when one possible line is 9...Qe7 10.0-0 Bxe5 11.Nb5!. Dubbed the "Flude Line" by Shaw after the Australian correspondence player David Flude, it often leads to wild complications that are difficult for either side to navigate at the board. The
Rice Gambit, 6...d5 7.exd5 Bd6 8.0-0?!, has been discredited. The main alternative to 7...Bd6 is 7...Bg7, the Deferred Paulsen Defense. The main line now is considered to be 8.d4 Nh5 9.0-0 Qxh4 10.Qe1 Qxe1 11.Rxe1 0-0 with equality. If Black does not protect the pawn, playing for example 6...Bg7?!, White should avoid 7.Nxf7?! Qe7 8.Nxh8 d5!; correct is 7.Bxf7+! Kf8 8.Bb3.
6.Nxg4 {{Chess diagram small Black often takes White's undefended pawn with 6...Nxe4. This invites the surprising forcing continuation 7.d3 Ng3 8.Bxf4 Nxh1 9.Qe2+ Qe7 10.Nf6+ Kd8 11.Bxc7+ Kxc7 12.Nd5+ Kd8 13.Nxe7 Bxe7, leading to an extremely imbalanced position where White is down a rook, bishop, and knight in exchange for Black's queen and one pawn. Black may exit the sequence by instead playing 8...Qe7+, which most commonly continues 9.Be2 Rg8 10.Bxg3 Rxg4 11.Bf2 Rxg2 12.Nc3. Black also often plays 9...Qb4+, threatening both White's bishop on f4 and pawn on b2. White usually responds by trading queens with 10.Qd2 Qxd2. Alternative sixth moves for Black include 6...d5, the
de Rivière Variation, typically continuing 7.Nxf6+ Qxf6, as well as 6...d6, transposing to the Kolisch Defense, and 6...Nc6.
6.d4 This is another common move, and most often continues 6...d6 7.Nd3 Nxe4 8.Bxf4 Bg7 9.c3, leaving an open center. 8...Qe7 is a common alternative for Black, enabling a discovered check if the knight on e4 moves. Thus, White usually responds with 9.Qe2 or 9.Be2. == Kolisch Defense: 5...d6 ==