Fermitin family homolog 2 (FERMT2) also known as pleckstrin homology domain-containing family C member 1 (PLEKHC1) or kindlin-2 is a protein that in humans is encoded by the FERMT2 gene.
Function
FERMT2 is a component of extracellular matrix structures in mammalian cells and is required for proper control of cell shape change. A major task of kindlins is to regulate the activation of integrins. == Interactions ==
Interactions
FERMT2 has been shown to interact with FBLIM1. ==Role in health and diseases==
Role in health and diseases
• Loss of kindlin-2 in mice leads to peri-implantation lethality. • Kindlin-2 is highly expressed in activated myofibroblasts for regulation of focal adhesion formation. • Deletion of Kindlin-2 retards insulin secretion and reduces β-cell mass in mice. • Elevated kindlin-2 expression was observed in tubular intestinal fibrosis of the kidney, a condition is characterized by massive expansion of the cortical interstitium, conversion of fibroblasts into myofibroblasts and progressive EMT of tubular epithelial cells. • Kindlin-2 is required for angiogenesis and blood vessel homeostasis. • Kindlin-2 can exert tumor-promoting or tumor-inhibiting functions based on tumor-type-dependent. • FERMT2 modulates the Alzheimer's Disease risk by regulating APP metabolism and Aβ peptide production. == References ==