In 1919 Edinburgh University bought the land of West Mains Farm in the south of the city with the intention of building a satellite campus specialising in the Sciences. The first building was the Chemistry Building (renamed the Joseph Black Building) designed by
Arthur Forman Balfour Paul in 1919. Building started in 1920 and was completed after 1924 by John Fraser Matthew. This was followed by the Zoology Building (renamed the Ashworth Laboratories) dating from 1929, also by Matthew. The name "King's Buildings" is a reference to then-king
George V. During
World War II, the Genetics Institute part of King's Buildings was used as the location for the first
War Office Selection Board. In 1968, the 10-story Darwin Tower was constructed at the campus, and became home to the Institute of Cell Biology.
Kenneth and
Lady Noreen Murray later made breakthroughs in genetic engineering here. Plans were announced to redevelop the site in March 2024, led by BMJ Architects. On 5 August 2014, the
FloWave Ocean Energy Research Facility was inaugurated by
Amber Rudd, then UK
Secretary of State for Energy and Climate Change. FloWave is a world-unique, diameter wave and current tank, primarily focused on testing marine energy technologies and projects. In 2021, the University of Edinburgh celebrated more than 100 years of the site with their KB101 campaign which included a lecture series and newly commissioned artworks by
Katie Paterson. In 2022, the new Nucleus building opened. This is a combined learning, teaching, and social hub at the heart of the campus. The £34m building was designed by architect Sheppard Robson, and built by
McLaughlin & Harvey during the
COVID-19 pandemic. In September 2025, the building was shortlisted for the
Royal Incorporation of Architects in Scotland Andrew Doolan Best Building in Scotland Award. In April 2026, the Engineering Forum building opened, home to the School of Engineering’s Institute for Energy Systems. The 5-story building hosts teaching and office spaces, as well as five research laboratories. It was the seventh building constructed for the university by McLaughlin & Harvey. ==Street and building names==