The economy of Kisii town is derived from commerce and agriculture. Crops and fruit cultivated around the area include maize,
managu, beans, bananas, pineapples, avocados, pawpaws etc. Cash crops in this area within and outside the municipality include coffee and tea which had been in existence before independence. Coffee processing within the municipality is also carried out. Kisii is the fastest growing town in western Kenya due to its high population, political stability and general tranquility. There is also food processing, health care, and education industries. Although it has few industrial activities, it has potential for larger agro-based industries due to its location in a rich agricultural area.
Soapstone quarrying takes place near the town around Tabaka, southwest of the town and a few kilometres off the Kisii-Isebania Road.
Coca-Cola had a bottling and distribution plant in Kisii municipality until 2017 when it was closed. The town hosts large supermarket chains and also hosts commercial banking and financial institutions' branches. Moreover, like many of Kenya's major urban centres, there is an influx of numerous other business ventures such as the hospitality sector with hotels, bars, restaurants, sports pubs, among other commercial activities. == Government ==