Kohautia grandiflora is a species of plant in the family Rubiaceae. It is widespread in the West African savanna, and can be found in most of the coastal countries from Mauritania to Namibia, although its presence in Côte d'Ivoire and Mali is considered doubtful. It grows as far east as Uganda and Sudan. It is also found in Madagascar, Yemen and Oman. It has been introduced in United States, Mexico, Cuba, Central America, and northeastern South America. It is an annual and grows primarily in the seasonally dry tropical biome.