The show stars
Ryōko Yonekura as Doctor-X – Daimon Michiko. Yonekura was a former fashion model who had performed as the first
Roxie Hart in the Japanese theater production of
Chicago in 2008. Takeshi Kitano returned to acting after a two-year absence for his role in the special. He had taken time off to work behind the camera. Tanaka was nervous during the whole three months of filming for the season because she had to work with Toshiyuki Nishida.
Masao Kusakari stars in the fifth season.
Main cast •
Ryoko Yonekura as Michiko Daimon (Doctor-X) A freelance surgeon who takes on the most difficult operations using unorthodox and dangerous methods. Her favorite catchphrase is "I never fail". •
Ittoku Kishibe as Akira Kanbara (Melon-Ojisan) The owner of Kanbara Medical Referral Agency and a former surgeon. Also another Doctor-X who was stripped of his medical License in Cuba. Known for his exorbitant prices and giving melons as gifts, given the nickname of Melon-Ojisan by Hiruma Shigekatsu. •
Yuki Uchida as Hiromi Jonouchi A anaesthetist who originally worked Full-Time in Season One. Resigned in the final episode and joined Kanbara Medical Referral Agency. She is a single mother, her ex husband is also a doctor who appeared in the series. • as Hideki Kaji One of the surgeons working for the University Hospital. He is known for his expertise in
laparoscopy. Dr. Kaji calls Dr. Daimon as "demon" due to how she doesn't follow status quo. This character is the only one with a spin-off in the series "Doctor-Y". •
Kosuke Suzuki as Mamoru Hara One of three recurring surgeons working for the University. Dr. Daimon calls him "Kin-chan". •
Kenichi Endo as Takashi Ebina One of the surgeons of Tōtei University Hospital, he is portrayed as someone who is weak to authority. He tries to be on Director Hiruma's good side by following his orders. •
Toshiyuki Nishida as Shigekatsu Hiruma One of the main antagonists of the series. In the series, he has been promoted, demoted, holding the position of hospital director or head of surgery. He tries to gain power by controlling top staff, taking advantage of Michiko's assignments, or through corrupt means. He also has tons of mistresses in and outside of the hospital.
Secondary Cast •
Kei Tanaka as Hikaru Morimoto Appearances: Seasons 1, 5 and 7 - A surgeon who left at the end of Season One to hone his skills overseas. In the premiere of Season 5, he returned to work in a rural area, but was transferred back to the main hospital by Shimura Madoka. In season 7 he returns briefly in episode 7 to Tōtei but now as a medical "Extuber" helping to provide good publicity. •
Shiro Ito as Ryunosuke Busujima Appearances: Seasons 1, 2 and 3 - The Director of the Hospital in Season One until he was fired due to underhand tactics by Hiruma Shigekatsu. In Season Two, he re-appeared to help Daimon Michiko in fulfilling her wish to operate on a patient. In Season Three, he appeared in the premiere and was rescued from an explosion on a cruise by Daimon. • as Takashi Torii Appearances: Seasons 1 and 5 - A professor serving as the Director of the Second Surgery Department at Teito III University Hospital in season 1. His hope for becoming the hospital's director was shattered when the former director fell ill and lost influence. In episode 6, he was diagnosed with cancer but concealed his diagnosis to participate in the upcoming academic conference. He fainted on the day of departure and was operated by Daimon in the season finale. He returned in season 5 after his recovery and served as the Deputy Director of the Surgery Department at Totei University Hospital. His personality changed due to his illness, prioritizing his patients over his academic work. He also lost his courage, following all of Hiruma's orders. •
Atsuko Takahata as Junko Shiraki Appearances: Seasons 3 and 7 - The head nurse at the NAMC in season 3. She takes pride in her work and always gives her all. She expects high standards from her nurses and is protective of them. She leads her nurses as an independent faction, shielding them from the center's political struggles. In season 7, she is shown to be working at a nurse themed hostess bar.
Season 3 •
Kin'ya Kitaōji as Yoshihito Tendo A former surgeon and current council member of the NAMC. He became the center's new director after Tetsuya Kurobe's dismissal in episode 1. His goal is to establish the Medical Industry Group to foster medical innovation for treating patients. He utilizes Michiko's successful operations to grow his influence to establish the group. He became the group's chairman after its establishment near the end of the season, but was promptly dismissed by the Cabinet of Japan due to political interference. After his dismissal, he realizes his negligence of the patients in front of him and vowes to return as a surgeon.
Season 7 •
Mansai Nomura as Ryutaro Hachisuka A former surgeon under Hiruma, now practicing internal medicine. He is the Director of internal medicine & Acting Director of the hospital when season 7 starts. He has a crush on Daimon Michiko, he also got his surgery done by her at the final episode.
Guest appearances Season one • Mansaku Fuwa as Jiro Ichinose, the president of Ichinose rubber company (Episode 1) •
Miyako Yamaguchi as Namiko Ichinose, Jiro's wife (Episode 1) •
Raita Ryū as Shigeru Kubo, Totei University Hospital director (Episode 1) •
Hirofumi Arai as Satoru Yasuda (Episode 2) • Midoriko Kimura as Mitsuyo Yasuda, Satoru's wife (Episode 2) • Kazuaki Hankai as Noboru Nikaidō, the president of Nikaidō Publishing company (Episode 2) •
Kami Hiraiwa as Mitsue Hanayama, a food blogger (Episode 3) • Shinsō Nakamaru as Tadashi Honda, Mitsue's lawyer (Episode 3) •
Shingo Tsurumi as Atsushi Yotsuya, a foreign fund manager (Episode 4) •
Tamao Akae as Mariko Yoshinaga, The Super Doctors program's host (Episode 4) • Akari Ninomiya as Saki Gokita (Episode 5) • Naomasa Musaka as Motohiko Rokusaka (Episode 6) •
Kayoko Kishimoto as Nanako Torii, Takashi Torii's wife (Episode 7–8) •
Koji Yamamoto as Takuya Hijikata (Episode 7–8) •
Kanji Tsuda as Ryo Yagi, a gossip magazine black journalist (Episode 8)
Season two •
Minori Terada as Kin'ya Ninomiya, the president of Ninomiya Real Estate company (Episode 2) •
Mirai Yamamoto as Torako Mimura (Episode 3) • Mayumi Myosei as Mika Kanie (Episode 3) •
Yumiko Shaku as Rumiko Shijō, the owner of Nakazono hostess bar in Ginza (Episode 4) • Hiroshi Ookochi as Ichirō Gomi (Episode 5) •
Fuka Koshiba as Kaori Gomi, Ichiro's daughter (Episode 5) •
Tetsuya Bessho as Mitsuhiko Kusakabe (Episode 5) •
Shigeru Izumiya as Rokusuke Kondo, Shinobu's father (Episode 6) •
Yumi Shirakawa as Hisae Asai, a Health Policy Bureau of
Ministry of Health, Labour and Welfare (Episode 7) •
Miyu Honda as Kurumi Murata (Episode 8–9) • Kaoru Okunuki as Mitsuyo Murata, Kurumi's mother (Episode 8–9) • Kenichi Kobayashi as Yasaku Takemoto, a fisherman (Episode 8)
Season three •
Naoko Otani as Haruko Busujima, Ryonosuke Busujima's wife (Episode 1) • Romeo Thomas as Bob First, a cruise crew's son (Episode 1) •
Akira Nakao as Tetsuya Kurobe, the director of National Advance Medical Center (Episode 1) • Moto Fuyuki as Jirō Tsukiji, a restaurant owner (Episode 1–2) •
Naoki Matayoshi as Shōji Kazama (Episode 2) • Seita Hosokawa as Kazuya Tsukiji, Jirō's son (Episode 2) •
Shima Iwashita as Masae Mihara, the chief of Japan Nurses Federation (Episode 3) • Ayaka Morita as Nanako Mihara, Masae's granddaughter (Episode 3) •
Takashi Matsuo as Hiroshi Yomo, a freelance journalist (Episode 4) • Walter Roberts as Albert Savarotti (Episode 4) • Seiichirō Uchida as Keiichirō Iiyama, the program host (Episode 4) •
Jun Inoue as Shingo Tanaka (Episode 5) • Hiroto Yoshimitsu as Hirohisa Igarashi (Episode 5) •
Noboru Kaneko as Takashi Rokko, an IT company director and Hiromi Jonouchi's high school classmate (Episode 6) •
Kyūsaku Shimada as Tatsuya Ichikawa, a Tokyo district prosecutor (Episode 6) • Mikito Nakawaki as Masakazu Uehara, a Tokyo district prosecutor (Episode 6) • Kei Sunaga as Takehiro Ōizumi, the
Minister of Health, Labour and Welfare (Episode 6) • Ginpunchō as Nanami Kotozuka (Episode 7) • Yukiko Takabayashi as Shizuko Suita (Episode 7) •
Seiran Kobayashi as Chihiro Yada (Episode 8) • Keiko Horiuchi as Kasumi Yada, Chihiro's mother (Episode 8) • Kazutaka Ishii as Kunio Yada, Chihiro's father (Episode 8) •
Nanao as Maya Kokonoe, a model (Episode 9) •
Judy Ongg as Yoshiko Tokachi, a
Diet member (Episode 9–11) •
Kazuyo Aoki as the owner of a hot spring (Episode 11) •
Takeo Nakahara as Minoru Hanyū, a
Chief Cabinet Secretary (Episode 11)
Special •
Kei Inoo (
Hey! Say! JUMP) as Kojirō Himuro, a figure skating champion •
Munetaka Aoki as Gen Akagi •
Manami Hashimoto as Harumi Kanazawa • Shōken Kunimoto as a stall owner • Kaito Takamura as Sōta Aoki, Gen's son
Season four • Daichi Watanabe as Jun Ichiki, an IT company director (Episode 1) •
Kei Yamamoto as Hideo Nioka, a village chief of Nijikawa, Yamagata (Episode 2) •
Yuriko Hoshi as Chiyoko Nioka, Hideo's wife (Episode 2) • Hiro Otaka as Ozaki, a village chief assistant (Episode 2) • Tokuma Nishioka as Yōji Kanemoto (Episode 2) • Kōichirō Sakai as Kanemoto's secretary (Episode 2) • Tamaki Shirai as Hideo's secret daughter (Episode 2) •
Yuki Matsushita as Misae Suyama, Saionji's former girlfriend and a former hostess (Episode 3) •
Saki Takaoka as Mirei Yotsuba, one of the Yotsuba sisters beauty unit (Episode 4) • Kinako Kobayashi as Mion Yotsuba, one of the Yotsuba sisters beauty unit (Episode 4) •
Yūichi Tsuchiya as Tetsuo Goto, a single father patient who had a metal allergy (Episode 5) • Ayumu Yokoyama as Shōta Goto, Tetsuo's son (Episode 5) • Ian Moore as John Starkey, a professor at Boston University (Episode 6) • Kenji Sakamoto as Rock Shrimp, Starkey's assistant (Episode 6) •
Shinji Takeda as Takashi Nanao, a famous deaf pianist (Episode 7) •
Kang Ji-young as Yuka Nanase, Nanao's assistant (Episode 7) • Minosuke as Kuniharu Yasuhara, Nanao's manager (Episode 7) •
Ryōsei Konishi as Yuta Yaotome, a superstar idol (Episode 8) • Manami Miyaji as Yumi Kawai, Yaotome's manager, later as Yaotome's wife (Episode 8) •
Shinobu Nakayama as Emi Kujō, a surgeon's wife at Keirin University Hospital (Episode 9) •
Toshihiro Yashiba as Taisuke Kujō, a surgeon at Keirin University Hospital and also Emi's husband (Episode 9) •
Jirō Dan as Haruo Samejima, a director of Keirin University Hospital (Episode 9) •
Hitomi Takahashi as Ritsuko Samejima, Haruo's wife (Episode 9) • Kōji Yano as Wang Chau, a businessman and founder of Wang International Clinic (Episode 10–11) • Shunsaku Kudō as Goto, Wang's translator (Episode 10–11) •
Meisa Kuroki as Tokiko, Wang's wife (Episode 10) • Charles Glover as Leonard Scoope, a presidential candidate (Episode 11) • Jenny Skidmore as Diana, Scoope's wife (Episode 11) •
Daimaou Kosaka as a delivery package courier (Episode 11)
Season five • Kazuyuki Matsuzawa as Kazuhisa Kurumada, a bus driver (Episode 1) •
Yoshikazu Ebisu as himself (Episode 1) • Takashi Masu as Tatsuo Isshiki, a medical journalist who having affair with Madoka Shimura (Episode 1) • Blake Crawford as Jichael Mackson, a surgeon from Boston University (Episode 1) • Mariko Akama as Isshiki's wife (Episode 1) • Yoshiko Nakada as Fujiko, Ito's mother (Episode 2) •
Mitsuru Hirata as Kotobuki Mikamo, a pricinpal of Totei University Kindergarten (Episode 3) • Eishi Ōfuji as Kenta, a Totei University Kindergarten student (Episode 3) • Yuira Gotō as Mei, a Totei University Kindergarten student (Episode 3) • Kōdai Matsumoto as Tsubasa, a Totei University Kindergarten student (Episode 3) •
Riisa Naka as Shiori Uchikanda (Episode 4) •
Shōtarō Mamiya as Goro Gotanda, a famous shogi player (Episode 5) •
Sei Hiraizumi as Yoshio Mutsuura, a Mikawaya gyoza restaurant owner (Episode 6) • Yoneko Matsukane as Atsuko Mutsuura, Yoshio's wife (Episode 6) •
Hiroki Konno as Shingo Urita, an anesthesiologist (Episode 6) • Hajime Tsukumo as Tamaki, a politician who operated by Inomata (Episode 6) •
Charlotte Kate Fox as Natasha Natinsky, a former surgeon and Hara's ex-girlfriend (Episode 7) •
Naho Toda as Sayuri Uchikanda, Kagenobu Uchikanda's wife (Episode 7) • Kiyoe Koiizuka as Nanaka, Uchikanda's cousin (Episode 7) •
Shōzō Hayashiya as Takuya Yakumo, a former secretary of
Minister of Health, Labour and Welfare (Episode 8) • Ayaka Imoto as Haruka Kokonoe, a ballet dancer student (Episode 9) •
Sachie Hara as Hisako Kokonoe, Haruka's mother (Episode 9) •
Kōhei Ōtomo as Setsurō Kokonoe, Haruka's grandfather and Hisako's father (Episode 9) • Kitaro as Kimoto, an orthopedic surgeon (Episode 9) • Hidekazu Nagae as a prosecutor who arrested Uchikanda (Episode 10) • Saki Seto as a prosecutor who arrested Hiruma (Episode 10)
Season six •
Masachika Ichimura as Nicholas Tange, a wealthy investor who was hired to restructure Totei University Hospital (Episode 1 - 10) •
Shinji Takeda as Yu Samejima, Tange right-hand man (Episode 1 -10) •
Mio Imada as Nurse Masako Oma (Episode 5-10) • Yusuke Itagaki as Kimihiko Ōyama, a special prosecutor (Episode 1, 7 ,9) • Moro Morooka as Toshirō Nisshiki, an CEO of Nisshiki Group (Episode 2) •
Moka Kamishiraishi as Yuri Nisshiki, Toshirō's daughter and Furusawa's girlfriend who later as his wife (Episode 2) • Shō Kiyohara as Kenji Furusawa, a domino expert and Yuri's boyfriend who later as her husband (Episode 2) •
Reiko Kataoka as Miyako Nisshiki, Toshirō's wife (Episode 2) • Takuzō Kadono as Saburō Umezawa, a politician (Episode 3) • Aki Nishihara as Kuniko Takeda, Umezawa's secretary and Hiruma's ex-lawyer (Episode 3) •
Shinichi Hatori as Customer T, a Monjaemon restaurant customer (Episode 3) • Tooru Tamakawa as Customer H, a Monjaemon restaurant customer (Episode 3) • Mitsuko Baisho as Yoshino, Ushio's mother (Episode 4) •
Kenshi Okada as Kiyoaki Yokkaichi, a world-renowned skater (Episode 4) •
Shima Iwashita as Masae Mihara, a chief of Japan Nurses Federation (Episode 5) • Kenji Anan as Goro Mihara, Masae's son (Episode 5) • Mayuko Saigō as Chiaki Mihara, Masae's granddaughter (Episode 5) • Gaku Oshida and Shieri Ohata as the naughty couple (Episode 5) • Hikakin as himself (Episode 5) • Yuni Akino as Megumi, a nurse at Nurse Station bar (Episode 5) • Umino Kawamura as Rika a nurse at Nurse Station bar (Episode 5) • Riku Toida as Shinnosuke Mihara, Masae's great grandson (Episode 5) •
Yūta Hiraoka as Shōta Rokkakubashi, a director of Hexagon Bridge and a billionaire (Episode 6) • Kahomi Takarabe as Mutsumi Minadzuki (Episode 6) • Eriko Kimura as Mutsumi's mother (Episode 6) • Alan Lowe as Seven Goldberg, a world banker (Episode 7) •
Ananda Jacobs as Natalie Goldberg, Seven's wife (Episode 7) •
Marika Matsumoto as Maria Nakayama, a surgeon at Totei University Hospital and later Hachimura's wife (Episode 8) •
Terunosuke Takezai as Masayoshi Hachimura, a politician who will be next prime minister and later Nakayama's husband (Episode 8) •
Ryudo Uzaki as Yuji Kudō, a famous rockstar (Episode 9) •
Mariko Tsutsui as Kyoko Kudō, Yuji's wife (Episode 9) •
Enon Kawatani as Takuya Niitsu, a singer-songwriter (Episode 9) •
Kairi Jō as Kazuto Yoshiyuki, a child pianist (Episode 9–10)
Season seven •
Ai Tominaga as Yuka Hitotsubashi, a member of
House of Councillors (Episode 1) •
Masaki Okada as Kei Ichiki (Episode 1) • Jasmine Rose as Nurse Jasmine, a nurse in New York who passes away (Episode 1) •
Mio Imada as Nurse Masako Oma (Episode 1 - 10) • Yui Natsukawa as Mayako Niki (Episode 2) • Ichirota Miyakawa as Yashiro Kanbe, the Vice Minister of Health, Labor and Welfare (Episode 3, 8) •
Maiko Kawakami as Kumiko Kanbe, Yashiro's wife who later divorced (Episode 3) • Kaname Ouki as Yuika Shiki, a musical actress (Episode 4) •
Reina Sumi as Kaede Hayami, Shiki's rival (Episode 4) • Taira Imata as Shunichirō Ōkawa, a member of
House of Representatives who having affair with Kaede (Episode 4) •
Nao Matsushita as Akari Nasuda (Nurse X), a freelance nurse (Episode 5) • Hajime Inoue as Kazuo Itsuki, a rectal cancer patient (Episode 5) • Yōko Kondo as Yōko Itsuki, Kazuo's wife (Episode 5) • Hayato Yoshida as Oh Miroku, a Chinese IT president's son (Episode 6) •
Toshie Negishi as Yasue Shichimiya, owner of (Episode 7) • Ito Iraishi as Moeka Shichimiya, Yasue's daughter (Episode 7) • Satoshi Tokushige as Sōshichi Enomoto, the
Minister of the Environment (Episode 7) • Yō Takahashi as Taichi Mukaishima, Sōshichi's secretary (Episode 7) •
Asaka Seto as Satsuki Yagami, Hiromi Jonouchi's high school classmate (Episode 8) • Gennosuke as Yuki Yagami, Satsuki's only son (Episode 8) •
Kazuki Kosakai as a sushi restaurant chef (Episode 9–10) • Mansour Diagne as Dr. Shelp, the director of Institute of Infectious Diseases from Safiristan (Episode 9–10) • Igor T. as Julius, Dr. Shelp's attendant who died after being infected (Episode 9–10) • Cookie as Masayoshi Kabutogawa, a construction consultant president (Episode 10) •
Hisako Manda as Katsuko Minami, governor of Tokyo (Episode 10) == Broadcast history ==