Efetov's major scientific interests are focused on molecular
immunology, evolutionary biology, and
biosystematics. Using spectral methods, he has demonstrated the existence of changes in the conformation of human
immunoglobulins at malignant tumors. He was the first to suggest using the insect proteins and peptides as molecule probes for investigation of the human proteins at norm and pathology. Efetov has established a new scientific approach – monoclonal immunosystematics that makes it possible to evaluate evolutionary relationships between the biological species through studying their proteins with use of
monoclonal antibodies. He has described one subfamily, 7 new genera and 11 subgenera of living organisms, discovered and described 37 new biological species inhabiting
Japan,
Korea,
Indonesia,
China,
Taiwan,
Vietnam,
Myanmar (Burma),
New Zealand,
India,
Russia,
Kyrgyzstan,
Turkmenistan,
Afghanistan,
Ukraine and
Hungary. Many times the results of his studies have been represented at international congresses and symposia held in different countries of Europe. In 2004, he initiated and hosted the International Symposium "Biology, Phylogeny, Molecular Biology, and Genetics of
Zygaenidae" at the Crimean State Medical University. He is the author of 665 scientific works that include over 25 monographs and 18 patents for inventions. His studies have been quoted in publications of scientists of 65 countries in 12 languages (including English, Hungarian, Spanish, Italian, German, French, and Japanese). He has trained one Doctor of Science and 5 Philosophy Doctors; currently (2023) he is supervising the writing of 3 dissertations. ==Awards and titles==