Broadway Nielsen has appeared in several Broadway shows. Her first appearance was in the 1985 production of
The Iceman Cometh as Pearl. She next appeared in
Jackie: An American Life (1997) playing various characters, including Rose Kennedy and Marilyn Monroe. In 2000 she played the role of Ninetta in a new production of
The Green Bird. In 2005, she played Eunice Hubbell opposite
Natasha Richardson's Blanche Dubois and
Amy Ryan's Stella in
A Streetcar Named Desire. In 2008 she played Madame de Volanges opposite
Laura Linney as Marquise de Merteuil in
Dangerous Liaisons and also played Anna in
To Be or Not to Be. In 2010 she played The Storyteller in
Bloody Bloody Andrew Jackson. She later appeared on Broadway in
Christopher Durang's play
Vanya and Sonia and Masha and Spike as Sonia. For this role, Nielsen was nominated for the 2013
Tony Award for Best Lead Actress in a Play. In 2014, she returned to Broadway, playing the role of Penny Sycamore in ''
You Can't Take It with You. She played the role until the show closed on February 22, 2015, after 169 performances. In 2017, she played the role of Monica Reed in the limited run of Present Laughter'', along with
Kevin Kline and
Cobie Smulders.
Off-Broadway Nielsen has appeared in numerous
Off-Broadway shows. She won an
Obie Award for
Best Actress for her role as Madeline Newell in
Dog Opera (1995). Nielsen won the Obie and a
Drama Desk Award nomination for
Best Featured Actress for her role as Mrs. Siezmagraff in ''
Betty's Summer Vacation (1999) by Christopher Durang. Her first Off-Broadway appearance was in a 1984 New York Shakespeare Festival production of Henry V at the Delacorte Theater in which she played Mistress Quickly. In 1988 she appeared opposite Laura Dern in The Palace of Amateurs''. In 2005, Nielsen starred as Veronica in
Christopher Durang's play
Miss Witherspoon at
Playwrights Horizons. In 2007 she played the lead role of Mary in
Crazy Mary by
A. R. Gurney at Playwrights Horizons, also starring
Sigourney Weaver. Nielsen portrayed Bootsie Carp in the 2007–08 production of
Charles Busch's
Die, Mommie, Die! at
New World Stages. She has also appeared at the
Guthrie Theater and in many regional theatre productions.
Film Nielsen's first film appearance was in the 1999 film
Advice from a Caterpillar. She next played the role of Emily Bailey in the
Woody Allen film
Small Time Crooks (2000). She has since appeared in the 2007 film
The Savages starring
Laura Linney, 2010's
Morning Glory starring
Rachel McAdams, and ''
That's What She Said'' (2012).
Television Nielsen's first television appearance was on a 1990 episode of
Tales from the Crypt. ==Stage==