Scientists, academics and technologists •
Clara Sousa-Silva, Astrochemist and science communicator •
Francisco D'Souza (born 1968), Indian American entrepreneur and businessman •
Gypsyamber D'Souza, American epidemiologist •
Marcelo Damy de Souza Santos (1914–2009), Brazilian physicist •
Octávio Tarquínio de Sousa (1889–1959), Brazilian historian and author •
Raissa D'Souza (born 1969), American theoretical physicist and computer scientist •
Ronald Bon de Sousa Pernes (born 1940), Canadian philosopher •
Teotonio R. de Souza (1947–2019), Indian historian
Visual artists •
Amadeo de Souza Cardoso (1887–1918), Portuguese painter •
Aurélia de Souza (1867–1922), Portuguese painter •
Francis Newton Souza (1924–2002), British painter from Goa •
Mauricio de Sousa (born 1935), Brazilian comic book artist •
Remo D'Souza (born 1974), Indian dancer, choreographer, actor and film director •
Solomon Souza (born 1993), Israeli artist, grandson of Francis Newton Souza •
Sofia Martins de Sousa (1870–1960), Portuguese painter •
Teresa Nunes Alves de Sousa (born 1979), Portuguese artist
Actors and filmmakers •
Andria D'Souza (born 1986), Indian television actress •
Edward de Souza (born 1932), British actor •
Genelia D'Souza (born 1987), Indian actress •
Karla Souza (born 1985), Mexican actress •
Krystal D'Souza (born 1990), Indian television actress •
Marjorie de Sousa (born 1980), Venezuelan actress and model •
Waluscha de Sousa (born 1979), Indian actress and model •
Steven E. de Souza (born 1947), American producer, director and screenwriter •
Sebastian de Souza (born 1993), British actor
Entrepreneurs •
Aron D'Souza, Australian businessman •
Francis deSouza (born 1970), American entrepreneur and business executive. •
Francisco Félix de Sousa (1754–1849), Portuguese-Brazilian slave trader •
Osmel Sousa (born 1946), Cuban-Venezuelan beauty pageant entrepreneur
Musicians, singers and composers •
Carmen Souza (born 1981), Portuguese-born singer and songwriter of Cape Verde •
Chris de Souza (born 1943), British classical music composer •
Gena Desouza (born 1997), Thai singer and actress •
Indigo de Souza (born 1996), American singer •
João de Sousa Carvalho (1745–1798), Portuguese composer of Baroque operas •
John Philip Sousa (1854–1932), American composer of marches •
Luciana Souza (born 1966), Brazilian singer •
Nikhil D'Souza (born 1981), Indian-born singer, songwriter and guitarist •
Raul de Souza (1934–2021), Brazilian trombonist •
Steve "Zetro" Souza (born 1964), American thrash metal singer
Writers and journalists •
Adelaide Filleul, Marquise de Souza-Botelho (1761–1836), French novelist •
Amílcar de Sousa (1876–1940), Portuguese doctor and author of health books •
Emma DeSouza, Irish writer, political commentator, campaigner, and peacebuilder •
Christovão Falcão (1512? – 1557), Christovão de Sousa Falcão, Portuguese poet •
Dinesh D'Souza (born 1961), Indian-American conservative political commentator, filmmaker and author •
Francis D'Souza, Canadian television executive and broadcaster •
Henrique "Henfil" de Souza Filho (1944–1988), Brazilian cartoonist, caricaturist, journalist and writer •
José de Sousa Saramago (1922–2010), Portuguese novelist, Prémio Camões and Nobel Prize in Literature •
Júlio César de Mello e Souza (1895–1974), Brazilian writer and mathematics professor; used the pen name
Malba Tahan •
Luís de Sousa (1555–1632), Portuguese monk and writer •
Manuel de Faria e Sousa (1590–1649), Portuguese historian and poet •
Márcio Souza (1946–2024), Brazilian novelist, essayist and playwright •
Maria Peregrina de Souza (1809–1894), Portuguese novelist, poet and folklorist •
Na D'Souza (1937–2025), Indian novelist and Kannada language writer •
Noémia de Sousa (1926–2003), Mozambican journalist and poet •
Ovídio de Sousa Martins (1928–1999), Cape Verdean poet •
Pete Souza (born 1954), American photojournalist, Chief Official White House photographer •
Tony D'Souza, American novelist, journalist and essayist
Political figures •
Aristides de Sousa Mendes (1885–1954), Portuguese diplomat •
Charles Sousa (born 1958), Canadian politician, Minister of Finance for Ontario from 2007 •
Christopher de Souza (born 1976), Singaporean Member of Parliament •
Dona Ana de Sousa, Ngola Ann Nzinga Mbande ( 1583–1663), Angolan queen •
Fitz Remedios Santana de Souza (1929–2020), Kenyan lawyer and politician •
Frances D'Souza, Baroness D'Souza (born 1944), British scientist and former Lord Speaker of the House of Lords •
Francis D'Souza (1954–2019), Indian politician, Deputy Chief Minister of Goa •
Herbert de Souza (1935–1997), Brazilian sociologist, politician and activist •
Jerónimo de Sousa (born 1947), Portuguese politician, General Secretary of the Communist Party •
Jose Philip D'Souza, Indian politician •
José Sócrates Carvalho Pinto de Sousa (born 1957), Portuguese politician and former Prime Minister of Portugal •
Luiz Martins de Souza Dantas (1876–1954), Brazilian diplomat •
Marcelo Rebelo de Sousa (born 1948), Portuguese politician, currently President of Portugal •
Márcio de Souza e Mello (1906–1991), Brazilian former air force general and member of ruling
junta •
Martim Afonso de Sousa (c. 1500–1571), Portuguese explorer and first Royal Governor of Brazil •
Paulo Renato Souza (1945–2011), Brazilian economist and politician •
Pedro Lopes de Sousa (? - 1594), Portuguese nobleman and first governor of
Portuguese Ceylon •
Sabrina De Sousa (born c. 1956), former American diplomat and ex-CIA operative •
Sérgio Sousa Pinto (born 1972), Portuguese politician, Member of the European Parliament •
Taíssa Sousa (born 1989), Brazilian politician •
Tomé de Sousa (1503–1579), Portuguese nobleman and first governor-general of Brazil •
Washington Luís Pereira de Sousa (1869–1957), last president of the First Brazilian Republic •
Boaventura de Sousa Santos (born 1940), economist and university teacher known for his work on the
World Social Forum and on Marxism
Athletes •
Abigail Conceição de Souza (1921–2007), Brazilian footballer •
Adrian D'Souza (born 1984), Indian field hockey player •
Adriano de Souza (born 1987), Brazilian footballer • •
Alan Goncalves Sousa (born 1997), Brazilian footballer •
Alexsandro de Souza (born 1977), Brazilian footballer •
Antao D'Souza (born 1939), Pakistani cricketer •
Artur de Sousa Pinga (1909–1963), Portuguese footballer and coach •
Cássio Alessandro de Souza (born 1986), Brazilian footballer •
Claudemir de Souza (born 1988), Brazilian footballer •
Cristiano Pereira de Souza (born 1977), Brazilian footballer •
Darius D'Souza (born 1989), Canadian cricketer •
Deivid de Souza (born 1979), Brazilian footballer •
Douglas Costa de Souza (born 1990), better known as Douglas Costa, Brazilian footballer •
Edson Edmar Dias de Souza, Mateus Paraná (born 1987), Brazilian footballer •
Erika de Souza (1982), Brazilian basketball player •
Fábio de Souza a.k.a. Fabinho (born 1975), Brazilian footballer •
Frederico Sousa (born 1978), Portuguese rugby player •
Gesias Calvancante Souza a.k.a. JZ Calvan (born 1983), Brazilian MMA fighter •
Givanildo Vieira de Souza a.k.a. Hulk (born 1986), Brazilian footballer •
Hélder Wander Sousa de Azevedo e Costa (born 1994), Portuguese footballer •
Hélia Souza (born 1970), Brazilian volleyball player •
Hudson de Souza (born 1977), Brazilian middle-distance runner •
Jenílson Ângelo de Souza a.k.a. Júnior (1973), Brazilian footballer •
João de Sousa (1924–2014), Portuguese rower •
João Sousa (born 1989), Portuguese tennis player •
Jorge Luiz Sousa a.k.a. Jorginho (born 1977), Brazilian footballer •
José Augusto Oliveira de Sousa (born 1974), Portuguese darts player •
José Carlos Leite de Sousa a.k.a. Sousa (born 1977), Portuguese footballer •
José Cristiano de Souza Júnior (born 1977), Brazilian footballer •
José Ivanaldo de Souza (born 1975), Brazilian footballer •
Kieren D'Souza (born 1993), Indian ultramarathon runner •
Marcelo de Souza (born 1975), Uruguayan footballer •
Marcelo de Souza Ramos (born 1978), Brazilian footballer •
Márcio Rafael Ferreira de Souza, a.k.a. Rafinha (born 1985), Brazilian footballer •
Marcus Vinicius de Souza, a.k.a. Marcus Vinicius (born 1984), Brazilian basketball player •
Marshall D'Souza (1941–2013), Pakistani-Canadian cricketer •
Nadson Rodrigues de Souza (born 1982), Brazilian footballer •
Paulo Manuel Carvalho de Sousa (born 1970), Portuguese former footballer •
Robert de Pinho de Souza a.k.a. Robert (born 1981), Brazilian footballer •
Robson de Souza a.k.a. Robinho (born 1984), Brazilian footballer •
Rodrigo de Souza Cardoso (born 1982), Brazilian footballer •
Romário de Souza Faria a.k.a. Romário (born 1966), Brazilian former footballer •
Ronaldo Souza dos Santos a.k.a. Jacaré (born 1979), Brazilian MMA fighter •
Sidney de Souza (athlete) (born 1966), Brazilian sprinter •
Sidney de Souza (equestrian) (born 1973), Brazilian equestrian •
Silvestre de Sousa (born 1980), Brazilian jockey •
Stephie D'Souza (1936–1998), Indian track-and-field athlete and hockey player •
Steven Jeffrey Souza, Jr. (born 1989), American baseball player •
Tony de Souza (born 1974), Peruvian wrestler •
Uênia Fernandes de Souza (born 1984), Brazilian racing cyclist •
Vágner Silva de Souza a.k.a. Vágner Love (born 1984), Brazilian footballer
Religious figures •
Albert D'Souza (born 1945), Indian Roman Catholic Bishop •
Aloysius Paul D'Souza (born 1941), Bishop of the Mangalore Diocese, India •
Basil Salvadore D'Souza (1926–1996), Bishop of the Mangalore Diocese, India •
Felipa de Souza (1556–1600), Portuguese-Brazilian lesbian convicted and tortured by the Inquisition •
Humberto Sousa Medeiros (1915–1983), Catholic Cardinal and Archbishop of Boston, Massachusetts •
James deSouza (1925–2016), Pakistani Roman Catholic priest •
João de Sousa (1647–1710), Archbishop of Lisbon, Portugal •
Norbert D'Souza, president of the All India Catholic Union during 1996–2000
Fictional characters •
Anna De Souza, in
Emmerdale TV series •
Bianca DeSousa, in
Degrassi: The Next Generation TV series • Lady Christina de Souza, in an episode of the British TV series
Doctor Who •
Daniel Sousa, in the
Agent Carter TV series and the
Agents of S.H.I.E.L.D. TV series. •
Donald De Souza, in
Emmerdale TV series • Etienne de Sousa, in ''
Dead Man's Folly'', a novel by
Agatha Christie •
Madame Souza, in
The Triplets of Belleville animated film •
Miles De Souza, in
Emmerdale TV series • Rodrigo De Souza, in
Mozart in the Jungle TV series by Amazon • Harry De Sousa, in "Mobland" TV Series
Other John Nicolas De Souza (1942) Venezuelan radio personality, Jazz concert promoter, creator of "Jazz y Algo Mas" magazine •
André Ventura Sousa (born 2000), Portuguese chess master •
Darryl De Sousa (born 1964 or 1965), American police officer •
Lino Sousa Loureiro,
2025 Mulhouse stabbing attack victim •
Moise de Souza, Beninese construction engineer and traditional aristocrat, head of the
De Souza family • Dame
Rachel de Souza (born 1968), British educationalist, and Children's Commissioner for England ==See also==