SOCS3

The expression of SOCS3 gene is induced by various cytokines, including IL6, IL10, and interferon (IFN)-gamma. For signaling of IL-6, Epo, GCSF and Leptin, binding of SOCS3 to the respective cytokine receptor has been found to be crucial for the inhibitory function of SOCS3. Overexpression of SOCS3 inhibits insulin signaling in adipose tissue and the liver, but not in muscle. But deletion of SOCS3 in the skeletal muscle of mice protects against obesity-related insulin resistance. For that reason, studies have shown that removal of the SOCS gene prevents against insulin resistance in obesity The SOCS3 protein can bind to JAK2 kinase, and inhibits the activity of JAK2 kinase. == Interactions ==

SOCS3 has been shown to interact with: • Erythropoietin receptor, • Glycoprotein 130, • Janus kinase 2, • PTPN11, and • RAS p21 protein activator 1. == Regulation ==

There is some evidence that the expression of SOCS3 is regulated by the microRNA miR-203, miR-409-3p and miR-1896. == See also ==