In 1886, he joined
Richmond Paper Company in
East Providence, Rhode Island, as a chemist, later becoming superintendent of a paper mill, and effectively recognised that the chemical engineering design was wrong: by correcting this, he came to his first patent. Further research and patents followed, mainly related to paper processing technology. Little left and formed his own company. He was joined by a colleague from Richmond Paper, Roger Griffin forming a new company in 1886, Little & Griffin, which was located in
Boston where MIT was also located. Griffin and Little prepared a manuscript for
The Chemistry of Paper-making which was for many years an authoritative text in the area. The book had not been entirely finished when Griffin was killed in a laboratory accident in 1893. After this tragedy, Little carried on in the business alone for a number of years. During these years he founded the Cellulose Products Company demonstrating that
cellulose acetate could be used in producing nonflammable wire insulation and artificial silk. The company didn't do well financially, and when it was dissolved,
Eastman Kodak purchased the company's patents for the first nonflammable motion picture film and the Lustron Company bought the artificial silk patents becoming the only American manufacturer of acetate silk. He collaborated with MIT and
William Hultz Walker of the MIT Chemistry department, forming a partnership, Little & Walker, which lasted from 1900 to 1905, while both MIT and Little's company were still located in Boston. The partnership dissolved in 1905 when Walker dedicated his full-time to being in charge of the new Research Laboratory of Applied Chemistry at MIT. Little continued on his own and formally incorporated the company, Arthur D. Little (ADL), in 1909. He conducted analytical studies, the precursor of the consulting studies for which the firm would later become famous. As chairman of the visiting committee of the department of chemistry and chemical engineering at MIT, he was responsible for the introduction of the Chemical Engineering Practice School. He also taught papermaking at MIT from 1893 to 1916. ==Honors==